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In this in silico study, researchers analyzed nonsynonymous SNPs in the LIPH gene linked to hypotrichosis and identified three potentially harmful variants (W108R, C246S, and H248N) out of 215 total, using sequence- and architecture-based bioinformatics techniques to differentiate between harmful and benign SNPs.

This article reports on a typical case of lichen planopilaris with foreign-body granulomas around hair shaft material, suggesting these may be an additional criterion for diagnosing late-stage LPP/FFA.

This study suggests that hairlessness in nude mice may be due to insufficient expression of phospholipase C-δ1, a molecule essential for normal hair development downstream of the Foxn1 gene.

This study found that coactivating LIN28B and follistatin enhances cochlear supporting cells' ability to regenerate hair cells in neonatal mice by reprogramming them into progenitor-like cells.

This study observed that in human scalp hair follicles, BTNL2 expression is lower in stressed conditions, which correlates with increased cytotoxic activity by gamma/delta and CD8+ T cells, suggesting a possible role for BTNL2 in controlling immune responses relevant to alopecia areata.

This study found that the long non-coding RNA lnc056 promotes the proliferation of hair follicle stem cells by upregulating TRIP6 expression through interaction with the transcription factor HNRNPUL1, suggesting a potential target for hair loss treatment.

This study discovered that the gene Tfap2b identifies a melanocyte stem cell population in zebrafish, essential for regenerating melanocytes with multi-fate potential into adult pigment cells.

This thesis found that desmoplakin mutations in cardiocutaneous syndrome are linked to dose-dependent disease severity and identified mechanisms by which KLHL24 mutations cause cardiomyopathy, with rescue experiments successfully preventing this phenotype in patient-derived heart tissues.

This study identified two cell surface markers, FAP and CD90, that distinguish between papillary and reticular fibroblasts in human skin, suggesting distinct functions and distribution in dermal layers.

This study diagnosed a group of six girls with various ectodermal abnormalities, identifying cranio-skeletal malformations consistent with focal dermal hypoplasia (Goltz syndrome), and found heterozygous mutations in the PORCN gene in two children.

This study found that mutations in the FGF5 gene are the primary genetic factor causing long hair in domestic cats through an autosomal recessive mechanism.

This study suggests that 3D spheroid cultivation of dermal papilla cells can restore their hair-inductive capabilities, which are lost in 2D-cultured cells.

This research found that deleting the SLC3A2 gene in hair follicle stem cells disrupts their maintenance and proper differentiation, leading to hair follicle growth defects and altered skin regeneration through a YAP/Taz-dependent pathway.

This study found that Flammulina velutipes polysaccharides-derived scaffolds greatly enhanced wound healing and hair follicle regeneration in a rat model, particularly with the FPS/NaOH variant showing the best results.

This study found that HIF-P4H-2 function in FoxD1-lineage cells is crucial for normal hair follicle development and homeostasis in mice, implicating disrupted HIF, TGF-β, and Notch signaling pathways in associated defects.

This study found that SFRP2 enhances Wnt3a-mediated β-catenin signaling in human dermal papilla cells, with higher SFRP2 expression in beard cells correlating with increased trichogenicity.

This study found that individuals with homozygous loss-of-function mutations in PLAAT3 experience a novel type of partial lipodystrophy linked to defects in white adipose tissue differentiation and function.

This study found that PRC2 plays a crucial role in maintaining intestinal homeostasis by supporting progenitor cell proliferation and limiting secretory lineage differentiation.

This article discusses platelet-rich plasma therapy for cicatricial alopecias like lichen planopilaris and reports no confirmed new clinical results; the authors highlight ongoing uncertainty about its effectiveness and potential risks.

This study identifies unique gene expression patterns in specialized fibroblasts within adult hair follicles, which advances understanding of their role in tissue regeneration.

This article presents a family case study of dermatopathia pigmentosa reticularis linked to a specific KRT14 gene variant, detailing symptoms and stressing the importance of molecular diagnosis for management.

This study found that the E2-ANGPT2 pathway is involved in hair follicle regulation and that ANGPT2 treatment increased hair density in modeled female pattern hair loss, suggesting potential therapeutic use.

This review outlines the current state of freeze-dried platelet-rich plasma (FD-PRP) research, emphasizing its use in wound healing, lumbar fusion, knee conditions, and dentistry, but reports no new clinical findings.

Early diagnosis and treatment can help manage fibrosing alopecia in older women.

This study identified novel isoforms of the PADI2 and PADI3 proteins, showing that PADI2β inhibits oligodendrocyte differentiation, possibly by opposing the effect of canonical PADI2, while PADI3β modulates the activity of PADI3α, suggesting new regulatory mechanisms of citrullination in tissue development.

This study developed a novel ferritin-based delivery system (LR@Fn) that effectively co-delivers RG108 and LLY283 for hearing loss treatment in animal models, reducing hair cell loss and synaptic damage more effectively than dexamethasone.

This study found that Fos protein expression is closely linked to epithelial cell differentiation, particularly during cornification and cell death, with overexpression observed in keratinization-blocked mutant epidermis.

This letter reports the first known Japanese case of autosomal recessive woolly hair/hypotrichosis with compound heterozygous mutations in the LIPH gene.

This review discusses the diverse roles of Frizzled proteins in developmental and homeostatic processes and reports no new experimental findings.