Characterizing the Cellular Diversity and Molecular Signatures Within the Hair Follicle Dermal Stem Cell Lineage

January 2017 in “ PRISM (University of Calgary) ”

Andrew Hagner

hair follicle dermal stem cell hfDSC fibroblasts Rspo2 Rspo3 Grem2 Hic1 FACS RNA-seq gene expression transcriptional programs mesenchymal cells stem cells fluorescence-activated cell sorting RNA sequencing

TLDR Unique genes in hair follicle cells help tissue regeneration.

The study focused on characterizing the cellular diversity and molecular signatures within the hair follicle dermal stem cell (hfDSC) lineage to better understand tissue regeneration and develop new wound-healing strategies. Researchers used a novel FACS strategy to isolate adult hfDSCs and their progeny, performing RNA-seq to establish gene expression signatures for specialized fibroblasts of the hair follicle. They identified signature genes, such as Rspo2/3, Grem2, and Hic1, that control fibroblast function. The research highlighted unique transcriptional programs that contribute to the functional heterogeneity among specialized fibroblasts within the adult hair follicle, enhancing the understanding of mesenchymal cell contributions to tissue regeneration.

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