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In this study, researchers used computational methods to identify six phytochemicals from nettle, saw palmetto, and fenugreek as effective binders to 5-alpha reductase, with Jamogenin showing enhanced stability when encapsulated in lipid nanoparticles.

In this study, among postmenopausal women with female androgenetic alopecia, the combination of Pygeum africanum and Serenoa repens extracts at higher doses plus MSM significantly increased total hair growth and hair resistance compared to a lower dose formulation after 16 weeks.

In this study, the researchers reported that the optimized compound 39 demonstrated potent AR antagonism and favorable pharmacokinetics in a hair-growth mouse model, achieving similar efficacy to pyrilutamide with faster onset and preserved safety, offering promise for next-generation topical AR antagonist development.

This study found that combining tamsulosin and finasteride significantly improved urinary symptoms and IPSS scores in elderly patients with benign prostatic hyperplasia compared to finasteride alone, with good safety profiles.

This study found that estetrol (E4) significantly prolonged the anagen phase and increased hair matrix keratinocyte proliferation in cultured human hair follicles, suggesting its potential as a treatment for female pattern hair loss.

In this study, a novel liposomal peptide formulation significantly enhanced hair growth in mice compared to minoxidil, but results on human tissue penetration were inconclusive, suggesting further research is needed for translation to human use.

This letter details a case report on platelet-rich plasma treatment for a patient with treatment-resistant frontal fibrosing alopecia, but it does not provide new clinical results.

This study reports that the newly optimized AR antagonist 39 demonstrated effective hair growth and safety in a mouse model of androgenetic alopecia, showing comparable efficacy to pyrilutamide with faster response and favorable pharmacokinetics, due to innovative structural design and dual metabolic inactivation strategy.

This review discusses the management options for recurrent ischemic priapism, noting that ketoconazole, finasteride, and other hormonal therapies may be effective but can have significant side effects; it reports no new clinical findings.

This study observed that piperonylic acid activated key signaling pathways in dermal papilla cells and increased hair growth markers, and a clinical trial showed users of a piperonylic acid formulation had more hair than those using a placebo, suggesting its potential for treating hair loss.

This study found that fibronectin nanofiber dressings, made using rotary jet spinning, accelerated wound healing and improved tissue restoration in a full-thickness wound mouse model.

This study reported no measurable effect on libido or other sexual life parameters in finasteride users compared to non-users among male participants examined with the Arizona Sexual Experience scale.

This study found that finasteride-loaded microspheres effectively treated androgenic alopecia in a mouse model, showing similar hair growth effects to orally-administered finasteride.

This pilot study found that using a topical Carica papaya latex gel for 28 days reduced hair fall and promoted hair regrowth in individuals with Indralupta, although the bald patch size did not significantly change, indicating the potential need for longer treatment or additional interventions.

This article discusses Propecia in dermatology but provides no new research findings.

This study confirms that finasteride inhibits the conversion of testosterone to dihydrotestosterone in human dermal fibroblasts, suggesting potential therapeutic use for androgen-related skin disorders.

This review found that topical finasteride has similar efficacy to oral finasteride in treating male and female pattern hair loss, with fewer systemic side effects, mainly causing localized scalp reactions like irritation and erythema.

In this study, researchers developed topical tofacitinib-loaded cationic lipid nanoparticles, which improved absorption and targeted hair follicles in an ex vivo pig ear model, showing promise in treating alopecia areata by reducing symptoms through the JAK/STAT pathway.

This study found that in male rats, hesperidin co-administration ameliorated finasteride-induced testicular toxicity by reducing oxidative stress and improving antioxidant status, sperm parameters, and enzyme activity compared to finasteride treatment alone.

This study found that finasteride reduced the severity of acne in both male and female patients without apparent side effects.

This study found that surface-modified liquid crystalline nanoparticles significantly enhanced skin permeation of finasteride and dutasteride compared to unmodified nanoparticles, suggesting potential for improved treatment efficacy in androgenetic alopecia.

In this study, a gel formulation with Fenugreek seed extract demonstrated beneficial effects in reducing hair splitting among patients compared to placebo.

The researchers reported an increased risk of malignant melanoma and nonmelanoma skin cancers with the use of angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, and thiazides in a large patient study.

This article discusses the global interest and market presence of biotin-based supplements like Folexin for preventing alopecia, but it reports no new research findings.

This study compiles current scientific knowledge on female pattern hair loss for aesthetic physicians, but it does not present new clinical findings.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

This study found that a nanotransferosome formulation of finasteride (FI-GO-NTF) in an Aloe vera gel significantly improved scalp permeation and antibacterial activity compared to standard formulations, suggesting safe and effective potential for alopecia areata treatment.

In this review, the authors found no evidence of harmful pregnancy outcomes from exposure to finasteride, and report that handling the medication poses negligible risk to a fetus.

This study found that finasteride significantly inhibits the metabolism of tirilazad to its active metabolites without greatly affecting tirilazad's overall clearance.