Evaluation of Risk of SSRI-Associated Impotence and Low Libido in Men Exposed to Finasteride

This document titled "Evaluation of risk of SSRI-associated impotence and low libido in men exposed to finasteride" from May 2016 reports on a study that aimed to evaluate sexual dysfunction adverse drug-drug interactions between finasteride (F) and selective serotonin reuptake inhibitors (SSRI). The study searched a large, urban, academic-based electronic medical record archive to detect all men exposed to oral F ≤ 1.25 mg/day, and with no record of impotence, low libido, nor phosphodiesterase-5 inhibitor use prior to F exposure. The study found that exposure to both F and an SSRI results in a clinically significant drug-drug interaction with an associated increased risk of both impotence and low libido in men who were prescribed both F and an SSRI in this study population.