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The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Miz1 is essential for proper hair structure and growth.

The right amount of retinoic acid is essential for normal hair growth and development.

Studying premature aging syndromes helps understand human aging and suggests potential treatments.

Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.

The conclusion is that genetic testing is important for diagnosing and treating various genetic hair disorders.

VDR regulation varies by tissue and is crucial for its biological functions.

Androgenetic alopecia is mainly caused by genetic factors and increased androgen activity, leading to hair follicle miniaturization.

A mouse gene mutation increases the risk of skin cancer.

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

Activating Notch signaling can kill basal cell carcinoma cells.

HLA-DRB5 and other genes may be linked to alopecia universalis.

Researchers found WNT10A to be a key gene in developing goat hair follicles.

Mice without certain skin enzymes have faster hair growth and bigger eye glands.

MILL molecules are unique immune proteins in mice that don't need TAP to appear on cell surfaces.

A Korean boy's skin and digestive symptoms were caused by a rare genetic disorder that affects zinc absorption, and he got better with zinc supplements.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.

The same genetic mutation in Sjögren-Larsson syndrome can lead to different levels of severity, suggesting other factors influence the symptoms.

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

LIPH mutations in Japan cause varying degrees of hair loss and woolly hair.

The genes KRT25 and SP6 affect curly hair in horses, with KRT25 also causing hair loss. If both genes are mutated, the horse gets curly hair and hair loss. KRT25 can hide the effect of SP6.

A protein found in safflower seeds can stimulate hair growth and speed up wound healing in mice.

A vitamin D receptor mutation causes rickets and affects immune responses.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Bmpr2 and Acvr2a receptors are crucial for hair retention and color.

Sox2 controls hair color by affecting pigment production in hair follicles.

Melatonin affects gene expression in goat hair follicles, potentially increasing cashmere production.

Genetic variants in PDE6H and LPAR6 cause vision impairment and hair loss in two Pakistani brothers.