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This study isolated a thermophilic bacterial strain, Bacillus cereus, from soil that produces an extracellular protease; the enzyme effectively removed non-leather structures from animal pelts and was compatible with commercial detergents.

In this study, researchers identified two novel peptidylarginine deiminases from treated rat keratinocytes, both showing enzyme activity with PAD‐R11 reflecting a characteristic of epidermal enzymes.

This study found that fibroblasts from Emery-Dreifuss muscular dystrophy patients with certain genetic mutations overexpress markers of fibrosis, and gene correction techniques reduced fibrogenic molecule expression in cell models, suggesting potential therapeutic applications.

In this study, researchers identified three root hair-specific peroxidases that may control cell wall properties during root hair cell expansion, affecting growth, enzyme activity, and cell wall structure.

This content contains no study findings or new results, instead referring only to statistical methods and figure captions.

In this study, researchers developed de novo designed hetero-bifunctional proteins as an alternative approach for targeted protein degradation, successfully targeting BCL-xL for degradation in cells and inducing apoptosis, which may expand the range of addressable E3 ligases and disease targets.

This study suggests that using glycosidases to lyse the polysaccharides of Botryoccocus braunii may allow for the semi-continuous recovery of hydrocarbons while keeping the cells viable.

This study characterized the CYP154C7 enzyme from *Streptomyces* sp. PAMC26508, highlighting its ability to hydroxylate steroids efficiently, particularly androstenedione, and identified key amino acids important for substrate selectivity and catalytic efficiency.

This study identified N-acyl arylsulfonamides, particularly N-(Boc-piperidine-4-carbonyl)-benzenesulfonamides, as steroid sulfatase inhibitors with improved cellular potency compared to previous compounds.

In this study, proteolytic enzymes applied to mice skin caused severe degeneration in hair follicles, including detachment of stem cells from their niche, suggesting potential impairment of stem cell function.

Certain enzymes react strongly with some hormones in rat skin during hair growth, mainly in sebaceous glands and hair sheaths.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

This study identified UBC22 as a novel E2 enzyme responsible for Lys11-linked ubiquitination in Arabidopsis, revealing its crucial roles in seed setting, female gametophyte development, and pathogen resistance.

This study reported that structure-guided engineering of CYP154C2 mutants significantly improved the 2α-hydroxylation of androstenedione and testosterone, with enhanced conversion efficiency and substrate selectivity compared to the wild-type enzyme.

In this study, researchers identified specific Se6OMT enzymes in *S. epigaea* involved in the cepharanthine biosynthetic pathway, providing insights into their substrate promiscuity and essential genetic components for metabolic engineering and synthetic biology applications of cepharanthine production.

This review discusses the progress and challenges of targeted protein degradation therapies, highlighting the increasing number of degraders in cancer clinical trials and the limited diversity in targeted proteins, primarily focusing on those employing CRL4^CRBN as the E3 ligase.

This article reviews the regulation and roles of spermidine/spermine-N(1)-acetyltransferase (SSAT) in polyamine metabolism and its potential as a target in cancer and other diseases, without reporting new experimental results.

The researchers reported that applying proteolytic enzymes to mice skin negatively affected hair follicles, leading to degeneration and potential impairment of stem cells from the bulge area.

This study found that novel compounds moderately inhibited 5α-reductase type 1 activity compared to finasteride, offering valuable data on structure-activity relationships.

This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.

This study observed that new trienone compounds consistently showed higher 5alpha-reductase inhibitory activity compared to corresponding dienones across various biological models.

This review discusses how transposable element activation may hinder tissue regeneration and explores mechanisms to control this activity, reporting no new experimental results.

RNase L suppresses regeneration in mammals.

This article reviews current therapies for exocrine pancreatic insufficiency in chronic pancreatitis, highlighting the challenges in achieving optimal enzyme dosing and the potential need for treatment even in asymptomatic patients.

This study used a zebrafish model and advanced mass spectrometry to identify 11 metabolites of epristeride, revealing significant effects on purine metabolism and aromatic amino acid biosynthesis, which may aid in developing anti-doping detection methods.

This study found that the metabolism of finasteride in rat hepatic microsomes involves key hydroxylation steps, highlighting the role of a novel enzyme in 6 alpha-hydroxylation.

This study reported that reconstructed skin models can be useful for studying the effects of non-water-soluble topical products on xenobiotic metabolism, particularly in enzyme activities like EROD and GST.

This review discusses the catalytic mechanisms and potential applications of nanozymes in areas like tumor therapy and biosensing, but reports no new experimental findings.

This study found that DGAT1 exhibits additional acyltransferase activities in vitro, including MGAT, wax synthase, and ARAT activities, suggesting these could be relevant to its in vivo functions.

This study found that four new progesterone derivatives reduced prostate weight in gonadectomized hamsters, suggesting potent in vivo antiandrogenic effects similar to finasteride.