Cutaneous Hydroxysteroid Dehydrogenases and Rat Hair Cycle
January 1975
in “
Archives of Dermatological Research
”
TLDR Certain enzymes react strongly with some hormones in rat skin during hair growth, mainly in sebaceous glands and hair sheaths.
The study investigated the histochemical activity of various hydroxysteroid dehydrogenases during a provoked hair cycle in rat skin. High reaction intensity was observed with dehydroepiandrosterone, estradiol, androsterone, and pregnenolone, while no reaction was noted with 11-beta-hydroxyprogesterone, testosterone, dihydrotestosterone, 17-alpha-hydroxypregnenolone, and 17-alpha-hydroxyprogesterone. The reactivity varied with the hair cycle, and the reactive sites were identified as the acini of sebaceous glands and the hair sheaths.
