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In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.

This study observed that hydrophobic modifications of hair matrix proteins significantly alter the humidity-dependent glass transition temperature of human hair.

This research outlines a chemical synthesis process for Finasteride, detailing the conversion of pregnadienolone acetate through various chemical reactions and modifications.

This study successfully synthesized finasteride using a method that avoids expensive reagents and column chromatography, achieving a higher yield than previously reported.

This review discusses strategies for treating hormone-dependent prostate diseases and synthesizes a range of potential 5α-reductase inhibitors, but experimental evaluation of these compounds was not completed.

This paper discusses the complex interplay between Long Covid symptoms and various chronic fatigue-related conditions but reports no new clinical findings.

This study found that an Enterobacter isolate demonstrated high resistance to selenate and effective sorption capacity, suggesting potential for bioremediation of selenium-contaminated environments.

This study aimed to examine traditional and modern treatments for androgenetic alopecia by reviewing existing literature, highlighting the condition's varied prevalence across different populations, with higher rates in men and notably lower in women and Eastern populations.

This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.

This study found that the mK6alpha and mK6beta genes in mice are regulated differently at the mRNA level, with implications for understanding K6 gene evolution and function in mammals.

This study suggests that mouse keratin 6 isoforms, K6a and K6b, have overlapping but distinct expression profiles, differing notably in their expression in suprabasal cells and response to phorbol esters.

This research reported that squarticles, nanoparticles made from sebum-derived lipids, enhanced the follicular delivery and skin accumulation of diphencyprone and minoxidil, indicating effective drug deposition with reduced systemic absorption in alopecia treatment.

This study found that human keratinocytes express a sodium-dependent multivitamin transporter for biotin, pantothenic acid, and lipoic acid, including a highly specific biotin transport component.

This study found that the most likely cause of hypercalcemia in a patient with symptoms of hypervitaminosis A and a history of chronic vitamin A ingestion was vitamin A toxicity.

This review surveys the chemical composition and various uses of jojoba oil in medicine and industry but presents no new clinical results.

This study observed that in Japanese females, hair lipid composition showed significant correlations, suggesting CH and CERs may act as a barrier against sebum-derived lipids.

This study found that in mice, deleting the keratin 10 gene enhances sebocyte differentiation and increases secretion of sebum and certain lipids without affecting proliferation-associated keratins.

This study suggests that Keratin 15 expression in stratified epithelia may be regulated by two distinct mechanisms involving PKC/AP-1 pathway for differentiation and FOXM1 for basal cells, challenging its reliability as a sole stem cell marker.

This study found that serine 44 in the N-terminal head domain of keratin 17 is phosphorylated in response to various stimuli affecting skin keratinocyte growth, linking K17 up-regulation with growth and stress responses in skin epithelium.

This study indicates that the normal human prostate is not a major contributor to circulating blood DHT concentrations in androgen-deficient patients receiving testosterone replacement therapy.

This study found that Runx1 in hair follicle stem cells modulates lipid metabolism, impacting membrane organization and enhancing signal transduction for cell proliferation in both normal and cancer epithelial cells.

This review highlights therapeutic options for inducing puberty in males and females with delayed puberty, emphasizing the need for larger trials to establish the best approaches.

Detecting steroid esters in cattle hair is inconsistent and influenced by sampling factors.

This study investigated lipid loss in hair caused by surfactants and found that surface and internal modifications can significantly protect different lipids from depletion, with internal modification preventing 52.0 to 81.3% of lipids in certain groups.

This study found an association between higher phthalate exposure and increased incidence of precocious puberty in girls, suggesting a need to reduce children's exposure to these endocrine disruptors.

This review discusses the role of acyl-CoA binding protein (ACBP) in the epidermal barrier, noting that its disruption in mice is linked to skin and fur abnormalities; it reports no new clinical results.

In this study, Far2-/- mice were observed to develop focal alopecia with altered sebaceous gland morphology and lower skin lipid levels compared to wildtype mice.

This study introduced a novel nonsteroidal androgen receptor antagonist that effectively controls sebum production in the golden Syrian hamster ear model through targeted follicular delivery.

This study found that among the tested analogs, compound 4e was the most effective in inhibiting wax esters in vivo in the Golden Syrian hamster ear model.

In this study, gender-affirming hormonal treatment was associated with increased hair growth, acne, and alopecia prevalence in transgender individuals assigned female at birth, while opposite dermatological changes were observed in those assigned male at birth.