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Epigenetic differences affect hair loss in identical Japanese male twins.

This study used advanced single-cell RNA and chromatin sequencing to investigate differences in peripheral blood cells between mild and severe alopecia areata patients, uncovering shared transcription factor motifs that may explain disease severity and open avenues for future research on therapeutic targets.

This article reviews how anatomical differences in skin arise and persist, and suggests the underlying molecular positional code is more complex than apparent, but reports no new research findings.

This article discusses differences in hair loss among monozygotic female twins despite identical genetics and reports no new clinical findings.

This study observed that in chicken skin, large-scale differences in gene expression between feathered and scaly skin are controlled by enhancer-driven uniform expression, while small-scale differences within individual feathers are associated with chromatin looping.

In this study, the authors review how epigenetic regulation influences the role of iPSC-derived neural stem/progenitor cells in spinal cord injury therapy, highlighting challenges in the cells' generation, differentiation, and transplantation, and the effect of therapeutic tools on these processes.

This study found that serum HDAC1 levels are significantly higher in patients with alopecia areata compared to those with acne vulgaris and healthy controls, suggesting potential therapeutic opportunities for HDAC inhibitors.

This study identified key genes and pathways related to wool follicle development in coarse wool lambs, suggesting epigenetic factors may influence wool sheep domestication and breeding.

This study found genetic variations, including de novo variants and copy number variations, that may be associated with phenotypic discordance in monozygotic twins with various clinical conditions.

This study found that both genome-wide screening methods identified the VTRNA2-1 epiallele as highly responsive to environmental influences, suggesting a link between early embryonic environment, epigenetic changes, and human disease.

This review revisits the mechanisms of wound induced hair follicle neogenesis in mice and concludes that the process involves canonical WNT signaling activated by Fgf9 from γδ T cells, but more research is needed to fully understand its cellular bases.

This protocol outlines a nationwide study to investigate the prevalence of metabolic and reproductive abnormalities, anxiety, and depression in Brazilian women with polycystic ovary syndrome, aiming to inform public health strategies.

This review summarizes the association between 5-alpha reductase inhibitors and depression, discussing potential mechanisms such as neuroactive steroid alterations and neuroinflammation, but reports no new clinical results.

Finasteride use may cause sexual dysfunction; more research needed.

This study suggests that HDAC inhibitors, such as Vorinostat and Entinostat, could be effective in promoting hair regrowth in a mouse model of alopecia areata.

This study provides genomic and epigenomic insights into the white wax scale insect, highlighting high methylation levels and differential hormone profiles linked to its sexual dimorphism and developmental differences.

This review discusses the dynamic changes in chromatin organization and nuclear morphology during cellular processes like differentiation and disease, highlighting recent advances in understanding these epigenetic mechanisms without presenting new experimental findings.

This study established an androgen-responsive human organ culture model using hair follicles, demonstrating that women's intermediate facial follicles grow more hair in response to men's higher androgen levels.

This review discusses sex differences in the neuroendocrine response to stress, focusing primarily on rodent studies, and highlights open questions about the roles of gonadal hormones and sex chromosomes.

This review examines how epigenetic dysregulation affects adult stem cell function, noting that impacts range from minor to serious disruptions in tissue homeostasis and potential cancer development.

This review discusses post-finasteride syndrome, emphasizing its serious psychological and cognitive symptoms and the need for more research and awareness in the medical community, but provides no new clinical findings.

This review highlights that the RNA modification N⁶-methyladenosine (m⁶A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.

This review discusses the roles of DNA methylation in skin development and regeneration, highlighting its impact on embryonic skin lineage, homeostasis, and potential therapeutic targets, but reports no new clinical results.

This study found that both genetic and epigenetic factors significantly influence age-related facial skin aging, with lifestyle and environmental factors also playing a substantial role.

This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.

This study suggests that genetic variants in the androgen receptor gene may predict which postmenopausal women with hair loss respond to finasteride therapy.

This study found that ferritin levels were positively associated with insulin resistance in non-diabetic Korean men and postmenopausal women, but not in premenopausal women.

This study found that testosterone and dihydrotestosterone are crucial for synaptic transmission and spine density in male hippocampal neurons, suggesting sex-specific effects of neurosteroids on brain development.

Girls with Autism Spectrum Disorder may show different symptoms than boys, leading to missed or delayed diagnoses.

This review discusses sex-based differences in immune responses, focusing on genetic, hormonal, and microbiome factors influencing infections like COVID-19, and reports no clinical results.