Epigenetic Regulation and Factors That Influence the Effect of iPSCs-Derived Neural Stem/Progenitor Cells (NS/PCs) in the Treatment of Spinal Cord Injury

The document reviews the role of epigenetic regulation in the use of induced pluripotent stem cells (iPSCs)-derived neural stem/progenitor cells (NS/PCs) for treating spinal cord injury (SCI). It emphasizes the challenges posed by epigenetic factors like DNA methylation and histone modification, which affect the generation, differentiation, and transplantation of iPSCs, impacting therapy quality and safety. The study highlights the potential of iPSCs in promoting neuronal regeneration and inhibiting inflammation but notes challenges such as improving iPSC generation efficiency and addressing epigenetic differences. It also discusses the influence of therapeutic tools like drugs and electrical stimulation on the epigenetic status of transplanted cells. The document calls for further research to optimize transplantation protocols and understand the interaction between epigenetic status and other therapeutic tools to enhance SCI treatment outcomes.