Epigenetic Regulation and Factors That Influence the Effect of iPSCs-Derived Neural Stem/Progenitor Cells (NS/PCs) in the Treatment of Spinal Cord Injury

This study reviews the role of epigenetic regulation in the use of iPSC-derived neural stem/progenitor cells (NS/PCs) for spinal cord injury (SCI) therapy. It highlights the challenges posed by epigenetic mechanisms, such as DNA methylation and histone modification, which affect gene expression and the quality of transplanted cells. The research examines how these epigenetic factors influence the generation, differentiation, and transplantation of iPSCs, and considers the impact of additional therapeutic tools like drugs and electrical stimulation on the epigenetic status of these cells. The study identifies key findings and future challenges in optimizing iPSC-derived NS/PCs for effective SCI treatment.