Prevalence and Characteristics of Polycystic Ovary Syndrome in Brazilian Women: Protocol for a Nationwide Case-Control Study

    October 2019 in “ BMJ Open ”
    Poli Mara Spritzer, Lucas Bandeira Marchesan, Betânia Rodrigues dos Santos, Felipe Vogt Cureau, Karen Oppermann, Rosana Maria dos Reis, Rui Alberto Ferriani, Rita Vasconcellos Weiss, Ricardo M.R. Meirelles, Ana Lúcia Cândido, Fernando M. Reis
    TLDR PCOS is common in Brazilian women and linked to metabolic and reproductive issues.
    The study investigated the prevalence and characteristics of polycystic ovary syndrome (PCOS) in Brazilian women, involving 800 women with PCOS and 400 controls. Conducted across eight university hospitals, it focused on metabolic and reproductive abnormalities, anxiety, and depression, using standardized procedures to explore clinical, genetic, and epigenetic traits. The study hypothesized regional variations in PCOS phenotypes due to differences in diet, ethnicity, and genetic backgrounds. It included physical examinations, blood and saliva samples for hormonal and genetic analyses, and pelvic ultrasounds. The comprehensive approach aimed to inform public health strategies for managing PCOS-related metabolic and reproductive issues in Brazil.
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