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Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

New compounds were made that effectively block a specific enzyme related to androgen conditions.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

The enzyme RDH12 plays a role in vision and retinal disease, with mutations leading to early onset visual loss and blindness, but the exact disease mechanism is unclear and there are no treatments yet.

Blocking IL-1 could help treat some hair loss conditions; alopecia affects liver detox systems; spironolactone is better than finasteride for female hair growth; focusing on the catagen hair phase could lead to new alopecia treatments.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.

Equisetum debile extracts may help with skin whitening, anti-wrinkle, and anti-hair loss treatments.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Losing weight and eating better are key to managing metabolic syndrome and its related conditions.

A complex X chromosome rearrangement can increase the risk of multiple autoimmune diseases.

Type 2 diabetes in youth is increasing, with high treatment failure rates and more severe than Type 1; certain drugs can lower lipid levels effectively with varying side effects, and apples may benefit heart health like statins but with fewer side effects.

Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.

The enzyme myo-inositol oxygenase is not linked to the cause of polycystic ovarian syndrome.

People with Myotonic Dystrophy type 1 are more likely to have certain skin conditions, but not more likely to get skin cancer.

PCOS has a strong genetic basis, but more research is needed to fully understand it.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

Seaweeds contain beneficial compounds with potential uses in food, cosmetics, and health, but more research is needed to improve extraction and safety.

Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.

Finasteride in male rats causes liver and metabolic issues in their offspring.

Ruxolitinib significantly improves multiple autoimmune conditions in APS-1 patients.

Deep eutectic solvents are eco-friendly and effective for extracting useful pharmaceutical compounds.

Compound 4 is a promising treatment for hair loss with low toxicity.