17β-Estradiol May Control Human Hair Follicle Growth Also via Up-Regulating the Expression of Cannabinoid Receptor Type 1

    April 2018 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Shinsaku Togo, Koji Sugawara, Ralf Paus, Daisuke Tsuruta
    Image of study
    TLDR 17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.
    The study investigated the role of 17β-estradiol (E2) in human hair follicle (HF) growth and found that E2 up-regulated the expression of cannabinoid receptor type 1 (CB1) in HF organ culture and outer root sheath (ORS) keratinocytes. This up-regulation suggested that E2 could increase HF sensitivity to the catagen-promoting effects of endocannabinoids, indicating a potential neuroendocrine regulatory mechanism. The findings proposed that combining topical E2 with a CB1 antagonist might improve the treatment of female pattern hair loss (FPHL).
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 8 results

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 9 months ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community We need to keep these snake oil companies accountable.

      in Treatment  119 upvotes 6 months ago
      Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

      community What has helped you regrow your temples?

      in Chat  21 upvotes 1 year ago
      User seeks advice for regrowing temples, currently using Fin, oral Min, and dermarolling. Suggestions include improving scalp environment and considering RU58841 or dutasteride.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 month ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

    Similar Research

    5 / 218 results