17β-Estradiol May Control Human Hair Follicle Growth Also via Up-Regulating the Expression of Cannabinoid Receptor Type 1

    May 2018 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Shinsaku Togo, Koji Sugawara, Ralf Paus, Daisuke Tsuruta
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    TLDR 17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.
    The study investigated the role of 17β-estradiol (E2) in human hair follicle (HF) growth and found that E2 up-regulated the expression of cannabinoid receptor type 1 (CB1) in HF organ culture and outer root sheath (ORS) keratinocytes. This up-regulation suggested that E2 could increase HF sensitivity to the catagen-promoting effects of endocannabinoids, indicating a potential neuroendocrine regulatory mechanism. The findings proposed that combining topical E2 with a CB1 antagonist might improve the treatment of female pattern hair loss (FPHL).
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