Effects of NGF and Estrogens on Human Hair Follicle In Vitro

    January 2004 in “ PubMed ”
    Zhuang-qun Yang, Junbo Tu, Tian‐Hua Yao, Xiaoge Zhao
    From the encyclopedia
    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Estradiol →

    an estrogen promoting hair regrowth more commonly used in women

    Studysummary In this study, NGF and minoxidil increased the growth of human hair follicles while 17 beta-E2 inhibited it; NGF also neutralized 17 beta-E2's inhibitory effect.
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    The study observed the effects of NGF, estrogens, and minoxidil on human hair follicle growth in vitro. It found that 100 ng/ml NGF and 125 micrograms/ml minoxidil significantly increased hair follicle growth compared to the control, while 0.5 microgram/ml 17 beta-E2 significantly inhibited growth. Additionally, the combination of 100 ng/ml NGF and 0.5 microgram/ml 17 beta-E2 showed no significant difference in growth, indicating that NGF could neutralize the inhibitory effect of 17 beta-E2. The results were supported by the rates of DNA synthesis measured through 3H-TdR incorporation.
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