Effects of NGF and Estrogens on Human Hair Follicle In Vitro

    January 2004 in “ PubMed ”
    Zhuang-qun Yang, Junbo Tu, Tian‐Hua Yao, Xiaoge Zhao
    TLDR NGF and minoxidil promote hair growth, while 17 beta-E2 inhibits it.
    The study observed the effects of NGF, estrogens, and minoxidil on human hair follicle growth in vitro. It found that 100 ng/ml NGF and 125 micrograms/ml minoxidil significantly increased hair follicle growth compared to the control, while 0.5 microgram/ml 17 beta-E2 significantly inhibited growth. Additionally, the combination of 100 ng/ml NGF and 0.5 microgram/ml 17 beta-E2 showed no significant difference in growth, indicating that NGF could neutralize the inhibitory effect of 17 beta-E2. The results were supported by the rates of DNA synthesis measured through 3H-TdR incorporation.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 129 results

      community Why do people here trust Kevin Mann?

      in Chat  34 upvotes 5 years ago
      Concerns about finasteride's side effects on neurosteroids and brain health, with skepticism towards Kevin Mann's advice. Users discuss using finasteride, minoxidil, and RU58841 for hair loss, with mixed opinions on their safety and effectiveness.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 1 year ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Please stop looking for a natural way to stop your hairloss

      in Chat  247 upvotes 3 years ago
      There is no natural way to stop hair loss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.

      community Ultimate Stack without nuking your gender (you'll go broke)

      in Treatment  82 upvotes 1 year ago
      A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

    Similar Research

    5 / 1000+ results