Effects of NGF and Estrogens on Human Hair Follicle In Vitro

January 2004 in “ PubMed ”

Zhuang-qun Yang, Junbo Tu, Tian‐Hua Yao, Xiaoge Zhao

nerve growth factor estrogens minoxidil 17 beta-E2 NGF estrogen Rogaine estradiol

TLDR NGF and minoxidil promote hair growth, while 17 beta-E2 inhibits it.

The study investigated the effects of nerve growth factor (NGF) and estrogens on human hair follicles in vitro. It found that 100 ng/ml of NGF and 125 micrograms/ml of minoxidil promoted hair follicle growth, while 0.5 microgram/ml of 17 beta-E2 inhibited it. Additionally, 100 ng/ml of NGF was able to neutralize the inhibitory effect of 0.5 microgram/ml 17 beta-E2 on hair follicle growth.

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