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research An unusual anatomical colocalization of alopecia areata and vitiligo in a child, and improvement during treatment with topical prostaglandin E2

14 citations , November 2009 in “Clinical and experimental dermatology”

This article presents a case report of a child with coexisting alopecia areata and vitiligo showing improvement with topical prostaglandin E2 treatment, without reporting new clinical results.

research Estudo comparativo da eficácia de intradermoterapia associada ou não a microagulhamento e solução tópica na redução da perda capilar em homens com alopecia androgenética

January 2023 in “Surgical & Cosmetic Dermatology”

This study examined the effectiveness of using intradermotherapy, with or without microneedling and topical solutions, in reducing hair loss among men with androgenetic alopecia, though results are not reported in the abstract.

research Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis

2 citations , February 2022 in “Journal of Pharmacy and Pharmacology”

In this study, two methotrexate-loaded liquid crystal formulations for topical application showed immunomodulatory effects and induced skin changes in mice with imiquimod-induced psoriasis.

research Alopecia androgenética masculina: um relato de caso de tratamento com microagulhamento associado a fatores de crescimento e minoxidil tópico

February 2020

This case report observed that a 44-year-old male patient with androgenetic alopecia experienced increased hair density and patient satisfaction after treatment with microneedling, growth factors, and minoxidil.

research 1370 17β-estradiol may control human HF growth also via up-regulating the expression of cannabinoid receptor type1 expression

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that in an ex vivo setting, 17β-estradiol increased CB1 expression in human hair follicles, suggesting possible sensitivity to endocannabinoids and a potential mechanism for hair therapy.

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community Why is no one talking about this? Topical dutasteride out performs oral finasteride.

in Finasteride/Dutasteride 180 upvotes 1 year ago

Topical dutasteride is considered more effective for hair regrowth with fewer side effects than oral finasteride. Users have mixed experiences, with some preferring topical applications for reduced side effects.

community Topical finasteride has affected my hormones

25 upvotes 2 years ago

A 21-year-old experienced hormone changes after using self-made topical finasteride for hair loss, including a 20% decrease in DHT, a 47% increase in testosterone, and a 39% increase in estradiol. The user previously used minoxidil and microneedling but is now seeking ways to balance hormones, possibly through supplements or dosage adjustments.

community 0.005% topical fin any experience?

4 upvotes 3 weeks ago

The conversation discusses using low concentrations of topical finasteride (0.005% and 0.02%) for hair loss due to concerns about side effects. One user suggests starting with higher doses and monitoring hormone levels, sharing their positive experience with higher doses of finasteride and dutasteride without side effects.

community Minoxidil 5%/FInasteride 0.1% topical - 4 weeks, am I seeing things or is there progress?

in Progress Pictures 28 upvotes 6 months ago

The user is using topical Minoxidil 5% and Finasteride 0.1% for hair loss and is concerned about potential side effects of oral treatments due to a history of depression and testosterone replacement therapy. Other users suggest that oral Finasteride may be more effective, but results typically take several months to a year to become noticeable.

community Estradiol (E2), Testosterone and DHT levels after 1 month on Dutasteride

in Research/Science 11 upvotes 1 year ago

Dutasteride and finasteride are used for hair loss, affecting hormone levels like DHT and testosterone. Hormone balance is crucial, as changes can lead to side effects such as increased estradiol and potential hair loss.

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Learn

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learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.
Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Minoxidil

Vasodilator used on the scalp and, at low doses, as a tablet

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin mainly hydrates the hair and scalp; no study has shown that it increases hair thickness or changes follicle function.

learn Valproic acid

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.

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