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    Glossary Enzyme Inhibition

    reduction or cessation of enzyme activity by specific molecules

    Enzyme inhibition refers to the process by which the activity of an enzyme is reduced or stopped. This can occur through various mechanisms, such as competitive inhibition, where an inhibitor molecule competes with the substrate for the active site, or non-competitive inhibition, where the inhibitor binds to a different part of the enzyme, altering its shape and function. Understanding enzyme inhibition is crucial in fields like pharmacology and biochemistry, as it can influence drug design and metabolic regulation.

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    1. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition Psychoneuroendocrinology · 2018 · 37 citations
    2. Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice 2017 · 16 citations
    3. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996 · 136 citations
    4. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex Journal of Biological Chemistry · 2009 · 47 citations
    5. GC–MS Profiling, Antioxidant, Enzyme Inhibition, Molecular Docking, and ADME Investigation of the <i>n</i> ‐Hexane Extract and the Essential Oil of <i>Platycladus orientalis</i> (L.) Franco Fruits Chemistry & Biodiversity · 2026
    6. Nipple Differentiation in Fetal Male Rats Treated with an Inhibitor of the Enzyme 5<i>α</i>-Reductase: Definition of a Selective Role for Dihydrotestosterone* Endocrinology · 1986 · 53 citations
    7. Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat Journal of Pain · 2009
    8. IN SILICO STUDY OF 12 PHYTOSTEROL COMPOUNDS IN MORINGA (MORINGA OLEIFERA LAMK.) SEED OIL ON 5Α-REDUCTASE ENZYME INHIBITION ACTIVITY AS ANTI-ALOPECIA International Journal of Applied Pharmaceutics · 2022
    9. 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid Journal of Supercritical Fluids · 2011 · 22 citations
    10. Phenolic composition, enzyme inhibitory, and antioxidant activity of Bituminaria bituminosa Food Science and Biotechnology · 2016 · 6 citations
    11. Inhibition of the pro-oxidant effects of benoxaprofen on poiymorpbonuclear leucocytes by retinol acetate in vitro British Journal of Dermatology · 1982 · 2 citations
    12. Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats Pharmacology Biochemistry and Behavior · 2010 · 13 citations
    13. Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin Nutrition research · 2021 · 3 citations
    14. Steroidogenic enzymes in skin. PubMed · 2001 · 21 citations
    15. Yangxuebushen Decoction prevents cyclophosphamide-induced hair loss by inhibiting hair follicle apoptosis Cutaneous and Ocular Toxicology · 2026
    16. Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine The Journal of Clinical Pharmacology · 1993 · 9 citations
    17. Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata JCI insight · 2016 · 222 citations
    18. Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition Discovery Medicine · 2025 · 3 citations
    19. Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development General and Comparative Endocrinology · 2009 · 60 citations
    20. Antioxidant and Cytoprotective Properties of Plant Extract from Dry Flowers as Functional Dyes for Cosmetic Products Molecules · 2021 · 48 citations
    21. Evaluation of 5α-reductase inhibitory activity of certain herbs useful as antiandrogens Andrologia · 2013 · 33 citations
    22. Formulation and optimization of transfersome containing minoxidil and caffeine Journal of Drug Delivery Science and Technology · 2017 · 32 citations
    23. Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice Journal of Cosmetic Dermatology · 2018 · 21 citations
    24. ENDOXAN ALOPECIA 1960 · 21 citations
    25. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005 · 20 citations
    26. Other Antiandrogens Dermatology · 1998 · 11 citations
    27. Targeting hirsutism: a new approach*1 Sexuality, reproduction & menopause · 2004 · 1 citations
    28. Common data base programs for accelerator physics Therapeutische Umschau. Revue thérapeutique · 1984 · 1 citations
    29. Endocrine treatment of benign prostatichypertrophy: Current concepts Urology · 1991 · 11 citations
    30. 한방복합처방단의 발모효과 및 멜라닌 생성 촉진효과 Journal of the Society of Cosmetic Scientists of Korea · 2011 · 1 citations