Endoxan Alopecia Study
August 1960
in “
British journal of dermatology/British journal of dermatology, Supplement
”
TLDR Endoxan often causes hair loss, which usually starts in the third week of treatment.
The study on Endoxan, a chemotherapy drug, found that 10 out of 25 patients treated in 1959 developed alopecia, which was not linked to the drug dosage, white cell count, or concurrent Röntgen therapy. Histological analysis indicated cellular disintegration in hair follicles, suggesting enzyme and mitotic inhibition as potential mechanisms. Alopecia usually started around the third week of treatment, with hair regrowth after stopping Endoxan, highlighting a notable incidence of hair loss among patients.
