Ascorbigen Induces Dermal Papilla Cell Proliferation In Vitro, But Fails To Modulate Chemotherapy-Induced Alopecia In Vivo

    March 2013 in “ Phytotherapy Research ”
    Chih Hsiu Wang, Hsu Shan Huang, Niann Tzyy Dai … Deh Ming Chang
    Studysummary This study found that ascorbigen increased growth of dermal papilla cells but did not significantly protect against chemotherapy-induced alopecia in a mouse model, suggesting limited effectiveness for hair regrowth in this context.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 11

    1. Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice Journal of Ethnopharmacology · 2011
    2. L-Ascorbic Acid 2-Phosphate Represses Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Balding Dermal Papilla Cells Experimental Dermatology · 2010
    3. L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase British journal of dermatology/British journal of dermatology, Supplement · 2009
    4. Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells Journal of Dermatological Science · 2007
    5. Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells Journal of Dermatological Science · 2006
    6. The Hair Growth Promoting Effect of Ascorbic Acid 2-Phosphate, a Long-Acting Vitamin C Derivative Journal of Dermatological Science · 2006
    7. Permanent Alopecia Following Chemotherapy and Bone Marrow Transplantation Australasian Journal of Dermatology · 2000
    8. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999
    9. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    10. Minoxidil as a Prophylaxis of Doxorubicin-Induced Alopecia Annals of Oncology · 1994
    11. The Therapeutic Use of Topical Minoxidil Dermatologic Clinics · 1990