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GlossaryCyclophosphamide (Endoxan)

chemotherapy drug that interferes with DNA replication in cells

Cyclophosphamide, also known as Cytoxan, is a chemotherapy drug used to treat various types of cancer and certain autoimmune diseases. It works by interfering with the DNA replication process in rapidly dividing cells, which helps to slow or stop the growth of cancer cells. However, it can also affect healthy cells, leading to side effects such as hair loss (alopecia) and increased risk of infections.

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research Endoxan Alopecia Study

21 citations , August 1960 in “British journal of dermatology/British journal of dermatology, Supplement”

Endoxan often causes hair loss, which usually starts in the third week of treatment.

research Cystitis Due to Cytoxan: Case Report

15 citations , May 1966 in “The Journal of Urology”

A woman developed severe bladder inflammation after cancer treatment with Cytoxan.

research Hormonal Parameters in Androgenetic Alopecia of the Male

September 1997 in “Journal of The European Academy of Dermatology and Venereology”

Hormonal differences affect male pattern baldness.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , January 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

In Vitro and In Vivo Evaluation of Biologically Synthesized Silver Nanoparticles for Topical Applications: Effect of Surface Coating and Loading into Hydrogels

research In Vitro and In Vivo Evaluation of Biologically Synthesized Silver Nanoparticles for Topical Applications: Effect of Surface Coating and Loading into Hydrogels

130 citations , January 2017 in “International journal of nanomedicine”

Silver nanoparticles coated with substances like PEG showed strong antibacterial effects and improved wound healing when used in hydrogels.

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community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

in Research/Science 3 upvotes 10 months ago

Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 1 year ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.