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Glossary Alkylating Agents

chemotherapy drugs that damage DNA to kill cancer cells

Alkylating agents are a type of chemotherapy drug that work by adding an alkyl group to the DNA of cancer cells, which interferes with their ability to replicate and ultimately leads to cell death. These agents are used to treat various types of cancer, but they can also affect normal cells, leading to side effects such as hair loss (alopecia).

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research Alkylating Agents

November 2013

This article reviews the history and dermatologic side effects of alkylating agents used in chemotherapy, noting that some agents like chlorambucil can cause recurrent symptoms upon rechallenge, whereas others are tolerated.

research Alkylation of human hair keratin for tunable hydrogel erosion and drug delivery in tissue engineering applications

75 citations , September 2015 in “Acta biomaterialia”

This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.

research Adverse cutaneous reactions to chemotherapeutic agents and cytokine therapy

18 citations , December 1996 in “Seminars in Cutaneous Medicine and Surgery”

This article reviews adverse skin reactions caused by chemotherapy and cytokine treatments, describing specific and nonspecific reactions, but reports no new clinical findings.

research Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood

16 citations , March 2017 in “Bone Marrow Transplantation”

In this study, permanent alopecia after haematopoietic stem cell transplantation was found in 16% of patients and was significantly associated with conditioning regimens involving busulphan.

research Cancer Treatments and Alopecia: A Systematic Review

2 citations , January 2021 in “Turkiye Klinikleri Journal of Internal Medicine”

This study outlines the temporary or sometimes permanent hair loss caused by cancer treatments, noting it often starts 2-3 weeks after chemotherapy and highlights the need for more research into prevention and treatment strategies for therapy-related alopecia.

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