Search

for
Search:

GlossaryAlkylating Agents

chemotherapy drugs that damage DNA to kill cancer cells

Alkylating agents are a type of chemotherapy drug that work by adding an alkyl group to the DNA of cancer cells, which interferes with their ability to replicate and ultimately leads to cell death. These agents are used to treat various types of cancer, but they can also affect normal cells, leading to side effects such as hair loss (alopecia).

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 304 results

research Alkylating Agents: History and Effects in Chemotherapy

November 2013

Alkylating agents can kill cancer cells but may cause skin and allergic reactions.

research Chemotherapy in Gynecologic Malignancy

March 1965 in “Hospital Topics”

Chemotherapy provides symptom relief and extends life in 30-50% of gynecological cancer cases, but has only cured choriocarcinoma.

research Permanent Diffuse Alopecia After Hematopoietic Stem Cell Transplantation in Childhood

16 citations, March 2017 in “Bone Marrow Transplantation”

Some children who had stem cell transplants developed permanent hair loss, especially when treated with a drug called busulphan.

research Iatrogenic Male Infertility

June 1998 in “Biomedicine & Pharmacotherapy”

Medical treatments like chemotherapy and radiotherapy can harm sperm production, so freezing sperm before treatment is important for men who want children later.

research Adverse Cutaneous Reactions to Chemotherapeutic Agents and Cytokine Therapy

18 citations, December 1996 in “Seminars in Cutaneous Medicine and Surgery”

Chemotherapy and cytokine therapy can cause various skin reactions, including hair loss and hypersensitivity.

View more "alkylating agents" in research →

Community Join

1 / 1 results

community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 12 upvotes 4 weeks ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.