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GlossaryAlkylating Agents

chemotherapy drugs that damage DNA to kill cancer cells

Alkylating agents are a type of chemotherapy drug that work by adding an alkyl group to the DNA of cancer cells, which interferes with their ability to replicate and ultimately leads to cell death. These agents are used to treat various types of cancer, but they can also affect normal cells, leading to side effects such as hair loss (alopecia).

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research Alkylating Agents: History and Effects in Chemotherapy

November 2013

Alkylating agents can kill cancer cells but may cause skin and allergic reactions.

research Adverse Cutaneous Reactions to Chemotherapeutic Agents and Cytokine Therapy

18 citations , December 1996 in “Seminars in Cutaneous Medicine and Surgery”

Chemotherapy and cytokine therapy can cause various skin reactions, including hair loss and hypersensitivity.

research Permanent Diffuse Alopecia After Hematopoietic Stem Cell Transplantation in Childhood

16 citations , March 2017 in “Bone Marrow Transplantation”

Some children who had stem cell transplants developed permanent hair loss, especially when treated with a drug called busulphan.

research Cancer Treatments and Alopecia: A Systematic Review

2 citations , January 2021 in “Turkiye Klinikleri Journal of Internal Medicine”

Cancer treatments often cause hair loss, and more research is needed to prevent and treat it.

research Iatrogenic Male Infertility

June 1998 in “Biomedicine & Pharmacotherapy”

Medical treatments like chemotherapy and radiotherapy can harm sperm production, so freezing sperm before treatment is important for men who want children later.

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community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 21 upvotes 10 months ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.