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    Glossary Alkylating Agents

    chemotherapy drugs that damage DNA to kill cancer cells

    Alkylating agents are a type of chemotherapy drug that work by adding an alkyl group to the DNA of cancer cells, which interferes with their ability to replicate and ultimately leads to cell death. These agents are used to treat various types of cancer, but they can also affect normal cells, leading to side effects such as hair loss (alopecia).

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    1. Alkylating Agents 2013
    2. Adverse cutaneous reactions to chemotherapeutic agents and cytokine therapy Seminars in Cutaneous Medicine and Surgery · 1996 · 18 citations
    3. Alkylation of human hair keratin for tunable hydrogel erosion and drug delivery in tissue engineering applications Acta biomaterialia · 2015 · 75 citations
    4. Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood Bone Marrow Transplantation · 2017 · 16 citations
    5. Cancer Treatments and Alopecia: A Systematic Review Turkiye Klinikleri Journal of Internal Medicine · 2021 · 2 citations
    6. Treatment of Chemotherapy Induced Alopecia IntechOpen eBooks · 2026
    7. Iatrogen male infertility Biomedicine & Pharmacotherapy · 1998
    8. Chemically Induced Depigmentation of Skin and Hair Springer eBooks · 1990
    9. Chemotherapy in Gynecologic Malignancy Hospital Topics · 1965
    10. Alkyl-Terminated Gold Nanoparticles as a Self-Therapeutic Treatment for Psoriasis Nano letters · 2021 · 19 citations
    11. Bendamustine: an Old Drug in the New Era for Patients with Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia Acta Clinica Croatica · 2018 · 9 citations
    12. Liposomes in cancer therapy Advanced Drug Delivery Reviews · 1989 · 21 citations
    13. An Update on Drug-Induced Pigmentation American Journal of Clinical Dermatology · 2018 · 20 citations
    14. Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy Nature Communications · 2019 · 32 citations
    15. Cutaneous complications of chemotherapeutic agents Journal of The American Academy of Dermatology · 1983 · 172 citations
    16. Conceptual Basis for Use of Chemotherapeutic Agents and Their Pharmacology Pediatric Clinics of North America · 1976 · 3 citations
    17. Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents Bioorganic & Medicinal Chemistry Letters · 2016 · 6 citations
    18. The Pharma Market as Reflected by Patents Drug Research · 2011
    19. Hair Loss Pattern due to Chemotherapy-Induced Anagen Effluvium: A Cross-Sectional Observation Dermatology · 2007 · 53 citations
    20. Adverse effects of common medications on male fertility Nature Reviews Urology · 2015 · 77 citations
    21. Pathogenesis and treatment options for chemotherapy‐induced alopecia: a systematic review International Journal of Dermatology · 2018 · 34 citations
    22. Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases Frontiers in Pharmacology · 2026
    23. Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents Aging Cell · 2023 · 48 citations
    24. Anticancer agents against malaria: time to revisit? Trends in Parasitology · 2010 · 39 citations
    25. LUPUS ERYTHEMATOSUS AND THE SKIN Elsevier eBooks · 2004 · 2 citations
    26. Molecular Targeted Agents and Biologic Therapies for Non-small Cell Lung Cancer Journal of thoracic oncology · 2010 · 12 citations
    27. Drug interactions between common dermatological medications and the oral anti-COVID-19 agents nirmatrelvir-ritonavir and molnupiravir Annals Academy of Medicine Singapore · 2022 · 5 citations
    28. Chitosan Nanoparticles for Topical Drug Delivery in Chemotherapy-Induced Alopecia: A Comparative Study of Five Repurposed Pharmacological Agents Pharmaceuticals · 2025
    29. Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents Molecules · 2022 · 20 citations
    30. Cytotoxicity of bendamustine, alone and in combination with novel agents, toward adult T-cell leukemia cells PLoS ONE · 2024 · 2 citations