TLDR Alkylating agents can kill cancer cells but may cause skin and allergic reactions.
The document discussed the history and effects of alkylating agents used in chemotherapy, starting with nitrogen mustard in 1946. These agents work by forming covalent bonds with DNA, leading to cell death. Dermatologic adverse events included hyperpigmentation, mucositis, alopecia, hypersensitivity reactions, and xerosis with pruritus. Extravasation could cause local cellulitis, though it was sometimes nonirritating. Rechallenge with chlorambucil caused the same symptoms, but other alkylating agents were tolerated.
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114 citations
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March 2002 in “Current opinion in oncology/Current opinion in oncology, with cancerlit” Cancer therapy can cause various skin problems, including hair loss, skin darkening, painful hand-foot syndrome, and severe skin damage.
53 citations
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May 2001 in “The American journal of the medical sciences” Chemotherapy can cause various skin problems, and recognizing them helps improve patient care.
275 citations
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March 1999 in “Journal of The American Academy of Dermatology” Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.
172 citations
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November 1983 in “Journal of The American Academy of Dermatology” Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.
