Alkylating Agents: History and Effects in Chemotherapy

    November 2013
    Elisabeth Livingstone, Lisa Zimmer, Lara K. Leister, Dirk Schadendorf
    TLDR Alkylating agents can kill cancer cells but may cause skin and allergic reactions.
    The document discussed the history and effects of alkylating agents used in chemotherapy, starting with nitrogen mustard in 1946. These agents work by forming covalent bonds with DNA, leading to cell death. Dermatologic adverse events included hyperpigmentation, mucositis, alopecia, hypersensitivity reactions, and xerosis with pruritus. Extravasation could cause local cellulitis, though it was sometimes nonirritating. Rechallenge with chlorambucil caused the same symptoms, but other alkylating agents were tolerated.
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