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This study found that the antiandrogen drug enzalutamide reduced TMPRSS2 levels and significantly decreased SARS-CoV-2 entry and infection in lung cells, supporting further clinical trials for COVID-19 treatment.

This study demonstrated that the antiandrogen drug enzalutamide may reduce TMPRSS2 levels in human lung cells and mouse lungs, supporting its potential as a COVID-19 treatment option.

This study found that the antiandrogens enzalutamide and bicalutamide reduced SARS-CoV-2 entry and infection in human lung cells by lowering TMPRSS2 levels, suggesting their potential as COVID-19 treatments and supporting clinical trials.

This essay explores the similarities in long-term health impacts of the COVID-19 and 1918 influenza pandemics, emphasizing how understanding medical history can guide better responses to post-epidemic health issues.

This study found that men receiving enzalutamide and other androgen-deprivation therapies may be at increased risk for QT prolongation and torsades de pointes.

This discussion proposes a model to incorporate patients with hormone-resistant prostate cancer into the existing framework by redefining hormone resistance and exploring new therapeutic approaches.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

This review discusses the role of the androgen receptor in breast cancer as a prognostic indicator and potential therapeutic target, highlighting its controversial therapeutic value and the need for further study.

This study found that cortexolone 17α-propionate (clascoterone) effectively inhibited androgen receptor-regulated transcription and IL-6 synthesis in scalp cells, potentially making it a promising candidate for topical treatment of androgenetic alopecia.

This study found that androgen impacted glucocorticoid signaling in the mouse brain only in the prefrontal cortex and substantia nigra, suggesting limited interaction between these hormones at high corticosterone levels.

This study found that androgen deprivation therapy is associated with an increased risk of acquired long-QT syndrome and Torsades de Pointes, particularly highlighting enzalutamide's greater association with sudden death compared to other therapies.

This study found that in vitro environments simulating testosterone levels in elderly males, testosterone and its metabolite DHT significantly reduced macrophages' ability to phagocytize MRSA and Pseudomonas aeruginosa, suggesting AR manipulation and inhibiting testosterone-DHT conversion might help fight wound infections in the elderly.

This review provides an overview of clinically approved small molecule drugs targeting androgen receptors and discusses therapeutic applications, without presenting new experimental results.

This study concludes that anti-androgenic chemicals causing short anogenital distance in male fetuses also induce a feminized transcriptional profile in the perineum, implicating Wnt and estrogen signaling in the process.

This research outlines that antiandrogens have mechanisms involving competitive inhibition of androgen binding and enzyme inhibition, with contraindications during pregnancy due to potential fetal risks.

This article reviews the diverse roles of protein kinase C (PKC) isozymes in cancer biology, highlighting their potential as therapeutic targets, but reports no new experimental results.

This review reports that myricetin, a naturally occurring antioxidant in plants, may assist in cancer management by enhancing the effects of existing drugs and inhibiting inflammatory markers, based on in vivo and in vitro studies.

This study found that taking oral FKH supplements for 90 days improved facial skin, hair, and nail appearance, and highlighted the role of free L-amino acids as potentially beneficial beyond their protein-building functions.

This study found that a 12-week regimen of a botanical supplement significantly improved skin and scalp health in women exposed to high pollution, enhancing factors like skin radiance, moisturization, and reducing wrinkle depth and scalp redness compared to a placebo.

In this clinical trial, supplementation with Lambdapil® Anti Hair Loss capsules for 6 months significantly improved hair resistance and volume in women and increased the anagen/telogen hair ratio in men, indicating enhanced hair growth compared to the placebo group.

The food supplement may help reduce hair shedding and improve hair growth.

The supplement may improve hair growth and quality in women with mild to moderate hair loss.

In this clinical study, the researchers found that a standardized wheat polar lipid complex, in both oil and powder form, significantly reduced hair shedding and improved hair growth in 99 women with acute telogen effluvium over 56 to 84 days.

This study found that a food supplement improved skin moisturization, elasticity, and thickness, reduced telogen hair density, and enhanced nail status in women with mild-to-moderate aging signs after 84 days.

This study demonstrated that a daily oral supplement of 1000 mg Kera-Diet® improved hair and nail conditions in women experiencing acute telogen effluvium and brittle nail syndrome over three months.

In this study, researchers found that supplementation with L-cystine, either alone or with a keratin hydrolysate, significantly improved hair density, hair and nail brightness, and nail growth in women experiencing acute telogen effluvium and brittle nail syndrome over three months.

This study found an association between atopic dermatitis and autoimmune diseases in both adults and children, with women more likely to experience these complications, but further research is needed due to limited participant numbers.

Male pattern hair loss could hint at androgens affecting COVID-19 severity.