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Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Minoxidil and finasteride effectively treat hair loss.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Treatments for melanin disorders exist, but more effective options needed.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.