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This review discusses recent advances in using stem cells for skin repair and regeneration after severe burn injuries, but it reports no new clinical results.

This study found that combining LED yellow light with an engineered strain expressing CXCL12 improved wound healing and reduced inflammation in a mouse model of scald wounds.

In this study, researchers used 3D bioprinting to successfully create engineered skin tissues with hair follicle-like structures, potentially enhancing skin grafts and safety testing for chemical compounds by more closely mimicking natural skin complexity.

This review explores advancements in bioprinting technologies for developing in vitro skin models that replicate immune-mediated skin diseases, highlighting their potential to reduce animal testing and enhance research and product testing capabilities in dermatology.

This review discusses how combining single-cell RNA sequencing and 3D bioprinting is advancing skin tissue engineering by enhancing cellular-level precision and addressing challenges like vascularization, ultimately improving regenerative outcomes and therapeutic strategies.

In this study, a bioengineered construct using a biodegradable polycaprolactone mat cocultured with human keratinocyte and rabbit dermal fibroblast cells demonstrated potential as a tissue-engineered skin substitute, showing good cell adhesion and growth.

This review discusses the characteristics and potential applications of epidermal stem cells in dermatology, without providing new clinical results.

This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.

New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.

This review discusses recent advancements in engineering bioengineered skin substitutes and highlights ongoing challenges, emphasizing the need for improvements in replicating uninjured skin; it reports no new experimental results.

This article discusses the applications and contraindications of skin grafts in wound treatment and reports no new research findings.

This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

This study found that using 3D Gel-C6S-HA scaffolds seeded with VEGF165-modified rat hair follicle stem cells enhanced angiogenesis and vascularization in tissue-engineered skin, improving wound healing.

This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.

This review addresses the limitations of current engineered skin substitutes for burn patients and highlights potential improvements through stem cell biology and skin morphogenesis, but it reports no new clinical results.

In this study, researchers successfully constructed a high-precision three-dimensional model of human skin dermis, revealing a detailed analysis of dermal porosity and pore diameter distribution, which can aid the development of biomimetic tissue-engineered skin.

This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.

This study found that using engineered skin with PGA-collagen scaffolds, combined with hair follicle stem cells and other cell types, effectively repaired full-thickness skin defects in nude mice.

This study found that fractional infrared technology may improve skin laxity and thickness in the cervical area without side effects in a small group of patients.

This review explores the potential of regenerative cosmetics, utilizing engineered skin tissues, to address aging, damage, and hair loss by enhancing collagen production, reducing wrinkles, and regenerating hair follicles, highlighting a transformative approach in dermocosmetics.

This review explores the potential of multifunctional bioscaffolds in skin tissue engineering, highlighting their successful biological performance in vitro and in vivo animal models, while also identifying the demand for technological advancements to improve wound healing applications in clinical settings.

This study observed that earlier-passage keratinocyte cultures led to superior hair follicle neogenesis in dermal-epidermal composites grafted onto immunodeficient mice, suggesting their potential utility in studying human hair follicle development.

This study reported that adipose-derived stem cells may promote burn wound healing and skin appendage regeneration in a rat model, suggesting a potential approach for improving burn treatments.

This study found that a new-type artificial xenogenic derma exhibited better biocompatibility and dermal tissue regeneration ability compared to cross-linked acellular dermal matrix in a mouse model.

This review discusses recent advancements in using macromolecules for hair loss treatment, highlighting microneedle and nanoparticle delivery systems, tissue-engineered scaffolds for hair follicle regeneration, and artificial skin platforms as drug screening methods.

This review discusses current concepts in wound repair and suggests that these evolving paradigms might also explain regenerative processes in various organ systems, but it reports no new research findings.

This review discusses the roles that mesenchymal stem cells may play in reepithelialization of wounds, but reports no new clinical results.

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.

This review suggests that induced pluripotent stem cells (iPSCs) hold promise for treating chronic wounds, but further work is needed to address safety, efficacy, and translation from preclinical models to real-world applications.