February 2025 in “International Journal of Bioprinting” This study constructed a 3D-printed scaffold using sodium alginate, gelatin, and alginate lyase hydrogel, which supports hair follicle regeneration in artificial skin, suggesting a promising strategy for tissue-engineered skin with functional appendages.
January 2024 in “Research Square (Research Square)” This study reports that adjusting the valence states of Mo in Pluronic F127-coated MoO3-x nanozymes enhances their selective H2O2-related catalytic activity, showing promise in acute kidney injury treatment and enabling real-time monitoring of therapy effectiveness through ROS-responsive photoacoustic imaging.
February 2017 in “International Journal on Advanced Science, Engineering and Information Technology” This study found that hair follicle stem cells can proliferate and differentiate into keratinocytes on chitosan skin-engineered templates, suggesting potential applications in regenerative medicine.
January 2013 in “Journal of Tissue Engineering and Reconstructive Surgery” This study found that inserting isolated hair follicle units into engineered dermis promoted differentiation and maturation of tissue-engineered skin, maintaining hair follicle morphology and generating skin appendages like sebaceous glands.
January 2011 in “Journal of Tissue Engineering and Reconstructive Surgery” This study found that incorporating dermal papillae cells and keratinocytes into dermal substitutes promoted better wound healing, reduced contraction, and enabled appendage formation in tissue-engineered skin on mice.
February 2009 in “Journal of The American Academy of Dermatology” This study found that fractional infrared technology may improve skin laxity and thickness in the cervical area without side effects in a small group of patients.
This review discusses recent advances in using stem cells for skin repair and regeneration after severe burn injuries, but it reports no new clinical results.
September 2004 in “Experimental Dermatology” This study developed a tissue-engineered model of innervated skin, allowing for examination of how epidermis and capillaries affect nerve growth and offering a tool for further research on skin-related processes.
December 2022 in “Acta Biomaterialia” Corrections were made to a previous work on 3D printing a gel-alginate mix for creating hair follicles, but the main finding - that this method can help grow hair - remains the same.
June 2021 in “Dermatologic Surgery” Tissue-engineered grafts can help regenerate hair follicles.
56 citations
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October 2024 in “Advanced Materials” The researchers suggest that advancements in bioprinting technology are promising but still face challenges in achieving human-scale, clinically applicable tissue constructs.
11 citations
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August 2022 in “Green Chemical Engineering” This review summarizes recent advances in the development of engineered polypeptide-based drug delivery systems for cancer therapy, highlighting their potential to improve treatment efficacy and reduce side effects.
7 citations
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December 2022 in “Frontiers in Bioengineering and Biotechnology” This review discusses the role of extracellular vesicles as therapeutic agents for wound healing and highlights the need for further research into their clinical applications.
This study found that a bioorthogonal microneedle patch delivering AAV-aFGF effectively improved hair follicle regeneration and sustained hair growth in murine alopecia models compared to other methods.
February 2026 in “Frontiers in Medical Technology” This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.
January 2026 in “Chemical Engineering Journal” In this study, researchers developed a programmable system using engineered nanovesicles from hair follicle stem cells to modulate immune responses, which showed promise in precisely controlling inflammation, promoting immune balance, and accelerating wound healing, particularly for infected wounds.
October 2025 in “Advanced Materials” In this study, researchers developed ionizable coenzyme Q10-engineered lipid/fiber microplexes that restored mitochondrial-ribosomal function and enhanced mRNA translation in senescent cells, leading to increased hair follicle density and bone formation in mouse models compared to conventional lipid nanoparticles.
December 2023 in “Aggregate” In this review, it is discussed how mesenchymal stem cell aggregation plays a crucial role in organ development and has potential applications in organ regeneration through tissue engineering.
April 2021 in “Journal of Investigative Dermatology” Early-stage skin substitutes improve wound healing and skin structure.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that incorporating Lef-1 transfected dermal papilla cells into human skin equivalents significantly promoted hair follicle differentiation and hair fiber growth, offering a potential advancement for managing skin loss.
January 2014 in “Journal of Tissue Engineering and Reconstructive Surgery” This study found that rabbit hair follicle stem cells, combined with electro-spun nano silk fibers, successfully constructed a tissue-engineered urethra, suggesting potential for future in vivo repair studies.
January 2006 in “Journal of Sun Yat-sen University” This study reports that tissue-engineered skin using ES cell-derived epidermal stem cells and collagen sponge successfully healed full thickness skin defects in mice, forming epidermis and structures resembling glands and hair follicles.
January 2023 in “Tehnika” This article discusses the challenges in diagnosing and treating autoimmune diseases, emphasizing the need for regenerative medicine approaches to address the root causes rather than just suppressing symptoms.
221 citations
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June 1999 in “In Vitro Cellular & Developmental Biology - Animal”
21 citations
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January 2018 in “The Korean Journal of Physiology and Pharmacology” This study found that human umbilical cord blood mesenchymal stem cells promoted hair growth by advancing anagen onset and increasing hair follicle regeneration in an in vivo model.
13 citations
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July 2022 in “Frontiers in cell and developmental biology” This review discusses the potential of cell-derived nanovesicles as innovative treatment strategies for hair growth and provides no new clinical results; the authors emphasize the need for further understanding of their mechanisms.
August 2026 in “Pharmaceutics” In this study, researchers developed a dexpanthenol-infused nanotechnological platform within hyaluronic acid hydrogels that promoted wound healing in mice by providing a protective barrier and significantly enhancing skin regeneration, including increased fibroblast activity and tissue remodeling.
July 2024 in “Journal of Investigative Dermatology” ATR12-351 ointment safely delivers LEKTI protein to the skin, reducing enzyme activity in Netherton syndrome.
May 2017 in “Journal of the American Academy of Dermatology” Modified stem cells can improve hair growth.
January 2015 in “D-Scholarship@Pitt (University of Pittsburgh)” This dissertation investigated barriers to clinical translation of adipose-derived mesenchymal stem cell-based vascular grafts, highlighting issues with thrombosis in diabetic patients and proposing alternative cell sources to improve applicability.