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The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

PCOS affects fertility and is linked to obesity and menstrual irregularities; lifestyle changes are recommended for treatment.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

COVID-19 and hypopituitarism (reduced pituitary gland function) are linked, with the latter's related health issues potentially worsening COVID-19 outcomes, and COVID-19 possibly increasing risk for pituitary complications.

Some skin diseases and their treatments can negatively affect male fertility.

Girls with PCOS have higher levels of certain androgens, which are linked to excess hair growth, but these androgens don't help diagnose PCOS.

Postmenopausal women with hyperandrogenism didn't have better metabolic health even after their testosterone levels became normal.

Skin problems in PCOS, like excess hair, acne, and hair loss, may not always indicate high male hormone levels and need careful diagnosis for proper treatment.

Some women with PCOS have rare genetic variants linked to the condition.

Men with high genetic risk for Polycystic Ovary Syndrome (PCOS) have increased chances of obesity, type 2 diabetes, heart disease, and hair loss, showing PCOS risk factors can affect both genders.

HIV medication ritonavir can increase the effects of nasal sprays like fluticasone, causing Cushing's syndrome.

Finasteride may worsen blood sugar control in diabetic patients.

Adults with classic congenital adrenal hyperplasia value medication that prevents weight gain from glucocorticoids the most.

A woman developed Cushing syndrome and adrenal insufficiency from using fluticasone and ritonavir together.

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Men have worse COVID-19 outcomes than women due to genetic and hormonal differences.

Ovarian stromal hyperplasia can cause high testosterone in postmenopausal women and is treated by removing the ovaries.

Early detection of ovarian steroid cell tumors is crucial to prevent lasting symptoms.

ACTH-dependent Cushing's syndrome linked to metastatic cervical cancer is rare and has high risks.

Hirsutism in young girls can have causes other than PCOS, so diagnoses should be reassessed if treatments don't work.

A rare ovarian tumor caused high testosterone in a postmenopausal woman, resolved by surgery.

Rare ovarian tumors can cause hyperandrogenism, even if imaging appears normal.

Bilateral salpingo-oophorectomy resolved hyperandrogenism in a postmenopausal woman with rare ovarian tumors.

Acute illnesses like sepsis can disrupt thyroid hormone balance without central hypothyroidism.

Rare ovarian tumors can cause hyperandrogenism, even if imaging appears normal.

Metastatic cervical cancer can cause rare, severe Cushing's syndrome with high risk of death.

Type B Insulin Resistance Syndrome is rare, linked to lupus, and hard to treat due to severe insulin resistance.

Ovarian steroid cell tumors can mimic adrenal hyperplasia, and surgery can normalize hormone levels.