Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

October 2024 in “ Journal of the Endocrine Society ”

Michael Salim, Sandhyarani Dasaraju, Youngjin Lee, Soha Afzal, Britt Erickson, Mahmoud Khalifa, Lynn A. Burmeister

postmenopausal hyperandrogenism alopecia testosterone androstenedione Leydig cell tumors Brenner tumor bilateral salpingo-oophorectomy hair loss androgen

TLDR Rare ovarian tumors can cause hyperandrogenism, even if imaging appears normal.

This case study describes a 66-year-old postmenopausal woman with hyperandrogenism and alopecia, ultimately diagnosed with rare ovarian tumors. Despite normal imaging, bilateral salpingo-oophorectomy (BSO) revealed bilateral Leydig cell tumors and a Brenner tumor. Post-surgery, her testosterone levels normalized, and alopecia resolved. This case highlights the diagnostic challenge of postmenopausal virilization and the necessity of surgical intervention for accurate diagnosis and treatment, especially when imaging does not reveal abnormalities.

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Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies

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27 citations, April 2017 in “European journal of endocrinology”

The research found that MRI and certain hormone levels can help tell apart ovarian tumors from hyperthecosis in postmenopausal women, but tissue analysis is still needed for a definite diagnosis.

research Postmenopausal Hyperandrogenism Associated With Synchronous Ovarian Brenner Tumor, Bilateral Leydig Cell Tumor, and Adrenal Mass

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A thorough diagnostic process and teamwork are crucial for managing complex hyperandrogenism in postmenopausal women.

Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

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research Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies

research Postmenopausal Hyperandrogenism Associated With Synchronous Ovarian Brenner Tumor, Bilateral Leydig Cell Tumor, and Adrenal Mass

research Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

research Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

research Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor