Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

    October 2024 in “ Journal of the Endocrine Society
    Michael Salim, Sandhyarani Dasaraju, Youngjin Lee, Soha Afzal, Britt Erickson, Mahmoud Khalifa, Lynn A. Burmeister
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    Studysummary This clinical case study reports on a postmenopausal woman experiencing hair loss and virilization symptoms, which were ultimately attributed to rare ovarian tumors identified after a bilateral salpingo-oophorectomy, despite normal imaging results.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This case study describes a 66-year-old postmenopausal woman with hyperandrogenism and alopecia, ultimately diagnosed with rare ovarian tumors. Despite normal imaging, bilateral salpingo-oophorectomy (BSO) revealed bilateral Leydig cell tumors and a Brenner tumor. Post-surgery, her testosterone levels normalized, and alopecia resolved. This case highlights the diagnostic challenge of postmenopausal virilization and the necessity of surgical intervention for accurate diagnosis and treatment, especially when imaging does not reveal abnormalities.
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