Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

October 2024 in “ Journal of the Endocrine Society ”

Michael Salim, Sandhyarani Dasaraju, Y. Lee, Soha Afzal, Britt Erickson, Mahmoud Khalifa, Lynn A. Burmeister

postmenopausal hyperandrogenism alopecia testosterone androstenedione Leydig cell tumors Brenner tumor bilateral salpingo-oophorectomy hair loss androgen

TLDR Rare ovarian tumors can cause hyperandrogenism, even if imaging appears normal.

A 66-year-old postmenopausal woman with a history of diabetes and breast cancer presented with worsening alopecia and other signs of hyperandrogenism. Laboratory tests revealed elevated testosterone and androstenedione levels. Imaging showed a stable left adrenal nodule, but no ovarian abnormalities. Adrenal and ovarian vein sampling indicated the ovaries as the testosterone source. A bilateral salpingo-oophorectomy (BSO) was performed, revealing bilateral Leydig cell tumors and a left ovarian Brenner tumor. Post-surgery, the patient's alopecia resolved, and testosterone levels normalized. This case highlights the diagnostic challenge of postmenopausal hyperandrogenism due to rare ovarian tumors.

View this study on doi.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 27 results

community REGROWTH AFTER 12 YEARS! My doctor approves of self-prescribed gray market internet dutasteride!!

in Female 72 upvotes 1 month ago

A woman experienced hair regrowth after using self-prescribed finasteride and dutasteride from online sources, despite doctors' reluctance to prescribe these due to potential birth defects. Her dermatologist acknowledged the effectiveness of these treatments and advised her to continue using them while avoiding pregnancy.

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 3 months ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.

community 9 months progress looks good to me

in Is this regrowth? 86 upvotes 5 months ago

A 35-year-old male reported positive hair regrowth after 9 months using oral dutasteride 0.5mg and oral minoxidil 5mg daily. A reply emphasized the importance of commitment and consistency for hair regrowth.

community One year of progress (Fin, 1mg)

in Is this regrowth? 281 upvotes 1 month ago

The user started finasteride (1mg) a year ago for hair thinning, experiencing stabilization but not significant regrowth. Suggestions included adding minoxidil, microneedling, and considering a hair transplant for improved results.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 759 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Similar Research

5 / 1000+ results

Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies

research Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies

27 citations, April 2017 in “European journal of endocrinology”

The research found that MRI and certain hormone levels can help tell apart ovarian tumors from hyperthecosis in postmenopausal women, but tissue analysis is still needed for a definite diagnosis.

research Postmenopausal Hyperandrogenism Associated With Synchronous Ovarian Brenner Tumor, Bilateral Leydig Cell Tumor, and Adrenal Mass

March 2024 in “Curēus”

A thorough diagnostic process and teamwork are crucial for managing complex hyperandrogenism in postmenopausal women.

Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

Related Community Posts Join

community REGROWTH AFTER 12 YEARS! My doctor approves of self-prescribed gray market internet dutasteride!!

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

community 9 months progress looks good to me

community One year of progress (Fin, 1mg)

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

Similar Research

research Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies

research Postmenopausal Hyperandrogenism Associated With Synchronous Ovarian Brenner Tumor, Bilateral Leydig Cell Tumor, and Adrenal Mass

research Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

research Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor

research Postmenopausal Hyperandrogenism Due to Rare Ovarian Tumor