Iatrogenic Cushing Syndrome and Secondary Adrenal Insufficiency Due to an Interaction Between Fluticasone and Ritonavir

May 2021 in “ Journal of the Endocrine Society ”

Lorena Suárez Gutiérrez

iatrogenic Cushing Syndrome secondary adrenal insufficiency fluticasone ritonavir alopecia ACTH cortisol beclomethasone CYP3A4 adrenal suppression Cushing Syndrome adrenal insufficiency Flonase Norvir hair loss adrenocorticotropic hormone steroid hormone Qvar cytochrome P450 3A4 adrenal gland suppression

From the encyclopedia

Hydrocortisone →

a synthetic cortisol used for anti-inflammatory effects

Beclomethasone →

Studysummary This case report describes a woman with HIV who developed iatrogenic Cushing syndrome and adrenal insufficiency due to the interaction between fluticasone and ritonavir, highlighting the need for careful management of corticosteroid use in patients on protease inhibitors.

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