2 citations
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June 2025 in “International Journal of Molecular Sciences” This review summarizes recent findings on the combined use of chitosan and melatonin, highlighting their synergistic effects in wound healing, anti-cancer therapies, and tissue engineering, with further potential applications in cosmetology, aesthetic medicine, and veterinary practice.
1 citations
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February 2026 in “ACS Nano” This study developed the TLMG hydrogel, a seamless in situ biointerface platform, demonstrating robust adhesion, high conductivity, and therapeutic effects for intelligent wound management in complex animal models and human tests, indicating its promise for integrated bioelectronic medicine.
1 citations
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October 2025 in “International Journal of Molecular Sciences” This narrative review highlights the potential of naturally occurring compounds to target specific molecular pathways and overcome resistance in advanced and recurrent papillary thyroid cancer, offering new therapeutic possibilities beyond traditional treatments like surgery and lifelong hormone replacement.
1 citations
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October 2025 in “Gels” This study demonstrates that pH-responsive nanogels designed with comb-like anionic polymers significantly improved oral delivery of the chemotherapy drug camptothecin, enhancing drug stability in acidic conditions and release in the intestines, with increased cellular uptake and cytotoxic effects against colorectal carcinoma cells.
1 citations
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January 2025 in “Molecules” This review reported that while glycyl-L-histidyl-L-lysine tripeptide copper complex (GHK–Cu) has limited skin permeation when used alone, liposomes may enhance its absorption, but there is limited research on this aspect, highlighting a need for further studies.
1 citations
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August 2024 in “Polymers” This review discusses recent advances in protein immobilization on bacterial cellulose for various biomedical uses and reports no new clinical results.
July 2026 in “International Journal of Molecular Sciences” This review highlights how cyclodextrin-polysaccharide hybrids can advance drug delivery and environmental cleanup by improving the solubility and stability of hydrophobic molecules, serving as promising platforms for biomedical applications and efficient sorbents for wastewater treatment.
This review highlights the potential of microneedles as a pediatric-friendly method for delivering proteins, vaccines, and diagnostics transdermally, noting their ability to penetrate the skin's barrier and suggesting future applications in other parts of the body.
January 2026 in “International Journal of Molecular Sciences” This review suggests that topically applied peptides may offer a promising alternative for managing pain in chronic wounds, with additional potential benefits of anti-inflammatory and regenerative activities, but acknowledges the challenges of delivering these peptides across damaged skin barriers.
December 2025 in “Sensors” In this review, recent advances in long-acting microneedle-based transdermal drug delivery systems are outlined, highlighting biodegradable polymers like PLA, PLGA, and PCL for sustained release and discussing challenges in clinical translation such as consistency in manufacturing and validating long-term efficacy and safety.
January 2025 in “AAPS PharmSciTech” Transethosomes improve drug delivery through the skin and show promise for treating various conditions.
October 2024 in “International Journal of Pharmaceutics” This study found that a topical formulation with nanostructured lipid carriers containing finasteride significantly restored hair follicles in androgenetic alopecia-induced rats without systemic absorption, suggesting its potential for safer and effective AGA treatment.
May 2024 in “International Journal of Nanomedicine” This review examined the diverse therapeutic potentials of cannabinoids, highlighting their applications in pain, neurological, and cancer treatments, and emphasized the benefits of biodegradable polymers in improving drug delivery; however, further clinical trials are needed to fully explore these potentials.
March 2024 in “Journal of pharmacy & pharmaceutical sciences” This review discusses the design strategies and applications of long-acting polymeric microneedles, noting their potential to improve patient compliance and reduce side effects in chronic disease management, but reports no new experimental results.
November 2023 in “ACS Omega” This study reported that a novel cationic liposome formulation for delivering encapsulated Cas9 protein and sgRNA successfully decreased SRD5α2 mRNA expression by 29.7% in vitro, suggesting a potential alternative treatment option for conditions like prostate cancer and benign prostatic hyperplasia without current drug side effects.
October 2023 in “International Journal of Pharmaceutics” This study found that ethosome-loaded minoxidil and tocopherol acetate improved hair regeneration and regulated the microenvironment around hair follicles better than commercial minoxidil in androgenic alopecia model mice, showing promise as a treatment strategy.
January 2023 in “Brazilian Journal of Pharmaceutical Sciences” This study concluded that the liquid chromatography-mass spectrometry method developed is viable for accurately quantifying spironolactone and its metabolite canrenone in plasma despite interference from plasma components.
December 2022 in “Journal of Experimental Biology and Agricultural Sciences” This study found that a specific combination of plant growth regulators effectively enhanced in vitro propagation and rooting of Eclipta alba, potentially enabling commercial-scale plant production.
156 citations
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March 2022 in “Exploration” This review discusses the development of bioactive inorganic particles-based biomaterials for skin tissue engineering and reports no new results; the authors highlight potential future directions for these materials in wound management.
31 citations
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April 2020 in “Pharmaceutics” This study found that dexamethasone nanocrystals significantly increased drug penetration into skin compared to a traditional cream formulation, suggesting potential benefits for treating inflammatory skin conditions.
2 citations
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September 2016 in “Journal of Dermatological Science” This study reported that squarticles, nanoparticle carriers made from sebum-derived lipids, significantly enhanced minoxidil delivery to hair follicles in vitro, increasing follicular uptake sevenfold and minimizing systemic absorption compared to a free control solution, while showing good skin tolerability.
September 2016 in “Journal of Dermatological Science” This study found that extracellular factors from a specific developmental stage can promote hair follicle neogenesis in adult skin by facilitating interactions between fibroblasts and keratinocytes.
8 citations
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May 2022 in “International journal of nanomedicine” This study developed a fully natural resveratrol nanoparticle system using lecithin, showing potent anti-cancer activity in vitro and increased tumoral uptake in vivo on breast cancer models.
151 citations
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November 2018 in “International Journal of Pharmaceutics” This review discusses various nanoparticles and nanoemulsions being investigated for transdermal drug delivery and reports no clinical results; it highlights potential applications in treating alopecia, wound healing, psoriasis, and melanoma.
140 citations
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August 2011 in “Biomaterials” This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.
53 citations
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May 1987 in “The Lancet” The document suggests a possible link between Crohn's disease and Johne's disease and calls for more research.
34 citations
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October 2021 in “Scientific Reports” This study found that nobiletin-loaded vesicles effectively restored skin condition in a mouse model of skin cancer, suggesting they are a promising treatment delivery system.
24 citations
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July 2018 in “Drug Design Development and Therapy” This study found that nano-transferosomal gel formulations of finasteride improved its delivery across skin layers, potentially reducing major side effects associated with oral administration for treating male pattern baldness.
23 citations
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March 2019 in “Environmental Chemistry Letters” This review examines the role of cyclodextrins in improving the solubility, stability, and bioavailability of steroid drugs but does not report new experimental findings.
20 citations
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March 2023 in “Drug Delivery and Translational Research” This study found that a lacticin 3147 solid lipid nanoparticle gel demonstrated potent and sustained antimicrobial activity against S. aureus, including MRSA, in ex vivo S. aureus-infected pig skin.