Melatonin/Chitosan Biomaterials for Wound Healing and Beyond: A Multifunctional Therapeutic Approach

June 2025 in “ International Journal of Molecular Sciences ”

Karolina Kulka-Kamińska, Patrycja Brudzyńska, M Okura, Tatsuyuki Ishii, Marco Skala, Rüssel J. Reiter, Andrzej Słomiński, Kazuo Kishi, Kerstin Steinbrink, Alina Sionkowska, Konrad Kleszczyński

melatonin chitosan antioxidant anti-inflammatory biocompatibility biodegradability moisturizing properties

TLDR Chitosan and melatonin together improve wound healing and have potential in medicine and cosmetics.

The document reviews the synergistic use of chitosan and melatonin in various therapeutic applications, highlighting their combined benefits in wound healing, anti-cancer therapies, tissue engineering, and drug delivery systems. Chitosan, known for its biocompatibility and biodegradability, offers antioxidant, antimicrobial, and moisturizing properties, while melatonin provides antioxidant, anti-apoptotic, and anti-inflammatory effects. Together, they enhance biomedical, pharmaceutical, and cosmetic applications, with potential uses in cosmetology, aesthetic medicine, and veterinary practice.

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Melatonin/Chitosan Biomaterials for Wound Healing and Beyond: A Multifunctional Therapeutic Approach

Research cited in this study

research Boosting Hair Growth Through Follicular Delivery of Melatonin Through Lecithin-Enhanced Pickering Emulsion Stabilized by Chitosan-Dextran Nanoparticles in Testosterone Induced Androgenic Alopecia Rat Model

research Wound Healing: Cellular Mechanisms and Pathological Outcomes

research Topical Melatonin for Treatment of Androgenetic Alopecia

research Melatonin and the Hair Follicle

research The Cutaneous Serotoninergic/Melatoninergic System: Securing a Place Under the Sun

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