Melatonin/Chitosan Biomaterials for Wound Healing and Beyond: A Multifunctional Therapeutic Approach

The document reviews the multifunctional therapeutic potential of melatonin/chitosan biomaterials, emphasizing their synergistic effects in wound healing, cancer therapy, and beyond. Chitosan's biocompatibility and antimicrobial properties complement melatonin's antioxidant and anti-inflammatory activities, enhancing wound healing and offering promise in anti-cancer therapies by inhibiting tumor growth and inducing apoptosis. These biomaterials also show potential in tissue engineering, bone regeneration, and dermatology, including as an alternative treatment for androgenic alopecia, improving hair loss without affecting serum melatonin levels. The combination's stability and efficacy are enhanced through encapsulation, making it a promising candidate for diverse biomedical applications.