The Development of a Solid Lipid Nanoparticle (SLN)-Based Lacticin 3147 Hydrogel for the Treatment of Wound Infections

    March 2023 in “ Drug Delivery and Translational Research ”
    Aoibhín Ryan, Pratikkumar Patel, Poonam Ratrey, Paula M. O’Connor, Julie N O'Sullivan, R. Paul Ross, Colin Hill, Sarah P. Hudson
    TLDR The new gel effectively treats MRSA-infected wounds for longer.
    The study developed a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for treating wound infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). Lacticin 3147, a bacteriocin from Lactococcus lactis, was encapsulated into SLNs to improve its physicochemical properties. The resulting gel demonstrated prolonged antimicrobial activity, maintaining effectiveness for 11 days compared to 9 days for a free lacticin gel. Both formulations showed significant bacterial eradication (>75%) on S. aureus-infected pig skin within 1 hour. This SLN-based gel offers a promising topical treatment for chronic wounds infected with S. aureus.
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