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research Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells
This study found that protein hydrolysates from mealworms, especially those derived using flavourzyme, significantly enhance adipogenic differentiation in 3T3-L1 preadipocytes, suggesting their potential as sustainable ingredients for glycemic control, skin health, and tissue regeneration products.
research Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants
This study found that liquid crystalline nanoparticles formulated with Cremophor surfactants significantly enhanced skin permeation of finasteride compared to lower surfactant concentrations.
research 5% Minoxidil: treatment for female pattern hair loss.
Recent Phase III trials reported that once daily 5% minoxidil foam significantly increased hair count in women with female pattern hair loss and was shown to be as effective as twice daily 2% minoxidil solution.
research Structure-guided PEGylated fibroblast growth factor 2 variants accelerate wound healing with improved stability
The researchers reported that PEG-FGF2 conjugates, particularly Compound 6, significantly enhanced stability, proliferation, migration, and wound healing activity compared to native FGF2, despite some reduction in bioactivity near crucial binding domains.
research Cutaneous Ultrastructural Features of the Flaky Skin (fsn) Mouse Mutation
This study reports that flaky skin mice exhibit skin and nail features that closely resemble human psoriasis vulgaris, suggesting they may serve as a natural model for this condition.
research Fibromodulin-Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors during Adult Mouse Skin Wound Healing
This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.
research Col4a2-eGFPmouse model reveals the molecular and functional dynamics of basement membrane remodelling in hair follicle morphogenesis
This study used a novel fluorescent tagging method in mice to observe collagen IV dynamics during hair follicle development, revealing that alterations in basement membrane turnover can influence epithelial progenitor cell behavior and organ morphology by affecting cell proliferation and movement.
research Fast Motions in 5 Alpha Reductase and Its Impact on Enzyme Kinetics
In this study, researchers using QM/MM simulations identified key molecular motions and residue interactions in the enzyme SRD5A2 that significantly influence its catalytic efficiency, demonstrating that specific residues play critical roles in stabilizing transition states and reducing activation barriers.
research 588 Skin fibroblast heterogeneity and plasticity are determined by the local niche
This study suggests that human skin contains distinct fibroblast subsets with unique expression profiles and functions, which can be isolated to investigate their role in skin pathogenesis.
research The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties
This study found that keratin 19, unlike keratin 14, forms less stable filaments with keratin 5, suggesting distinct assembly properties and potential unique roles in skin basal cells.
research LB1045 Inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo
PP405 may help hair growth by activating hair follicle stem cells.
research De novo filament formation by human hair keratins K85 and K35 follows a filament development pattern distinct from cytokeratin filament networks
In this study, transfection experiments showed that mutations in the K85 gene affect filament formation with K35, which may impact hair formation related to ectodermal dysplasia.
research A Fibrous Hybrid Patch Couples Cell-Derived Matrix and Poly(l-lactide-co-caprolactone) for Endothelial Cells Delivery and Skin Wound Repair
This research found that a biodegradable fibrous membrane incorporating fibroblast-derived ECM accelerated wound healing and improved neovascularization in a mouse model.
research Reply to «Facial Papules in Frontal Fibrosing Alopecia: Good Response to Isotretinoin»
Isotretinoin at low doses effectively treats facial papules in frontal fibrosing alopecia.
research Tinea favosa: psoriasiform favus in bindi area of an adult
This case report highlights an atypical presentation of favus in an immunocompetent adult, where a psoriasiform plaque over the 'bindi' area was successfully treated with systemic itraconazole, achieving complete resolution without relapse. Simple stains proved essential for diagnosis in this resource-limited setting.
research Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds
In this study using a mouse model, researchers found that expressing Lef1 in dermal fibroblasts may enhance skin regeneration without affecting normal development.
research Frontal fibrosing alopecia: Iatrogenic endocrine disruption
Certain drugs and supplements may contribute to hair loss in the frontal hairline in older women.
research Fibrotic enzymes modulate wound‐induced skin tumorigenesis
PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.
research Abstract P5-21-05: ERALOP study: Post adjuvant FEC - docetaxel chemotherapy for early breast cancer: Hair regrowth in the real life
This study found that persistent significant alopecia was a common side effect following FEC-docetaxel chemotherapy, with a 33.4% global incidence, highlighting the need for awareness and potential preventative measures like cooling caps during treatment.
research A Randomised-Controlled Study Demonstrates That Diet Can Contribute to the Clinical Management of Feline Atopic Skin Syndrome (FASS)
This study found that a novel pet food formulation significantly improved the management of feline atopic skin syndrome by reducing symptom severity and medication dependence over six months in client-owned cats, compared to a control diet.
research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes
This study investigated how secretions from cultured human hair follicle-derived keratinocytes affect gene expression in human follicle dermal papilla cells to understand their signaling interactions.
research Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway
This study found that LGR5 is uniquely expressed in human corneal endothelial cells and maintains endothelial cell phenotypes while inhibiting mesenchymal transformation through the Wnt pathway.
research Evolutionary Divergence of Fibroblast Growth Factors Across Species: Insight into Functional Diversification
This study suggests that fibroblast growth factors exhibit significant expression differences in rodent and primate skin, potentially related to their evolutionary paths and environmental adaptations.
research Revival of favus in Japan caused by Trichophyton schoenleinii
This report details a rare case of favus in Japan, identifying Trichophyton schoenleinii in a 63-year-old woman through DNA sequencing, who was successfully treated with oral terbinafine and topical luliconazole.
research Case series of familial frontal fibrosing alopecia and a review of the literature
This study reports that familial frontal fibrosing alopecia was diagnosed earlier in premenopausal women compared to postmenopausal women, though long-term outcomes remain uncertain without a definitive treatment.
research FFA Patient Profile Analysis Based on the Authors’ Observations and a Review of the Literature—An Original Survey
This study reported that frontal fibrosing alopecia predominantly affects postmenopausal women and identified potential risk factors like frequent β-blocker use and sunscreen application, indicating the need for further research.
research 5 Alpha-Reductase Inhibitor
This study found that finasteride treatment may decrease contraction of seminal vesicle tissue and alter some semen parameters in male rabbits.
research 42577 Application of the new clinical guidelines in frontal fibrosing alopecia of the male
This study examined the application of new clinical guidelines for diagnosing frontal fibrosing alopecia in 18 men, highlighting that current diagnostic criteria may often overlook early beard involvement and sideburn recession.
research Long-term staining of live Merkel cells with FM dyes
This study found that FM dyes are effective markers for tracing live Merkel cells in in vitro experiments, as they remain visible for at least seven days and highlight cell shape better than quinacrine.