November 2025 in “ACS Omega” This study found that compounds from *Tectona grandis* leaves showed moderate inhibition of steroid 5α-reductase, a factor in androgenetic alopecia, and exhibited anti-inflammatory properties by inhibiting nitric oxide and pro-inflammatory cytokines IL-1β and IL-6 in vitro, suggesting potential dual-action benefits for AGA management.
October 2025 in “Bioactive Materials” This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.
August 2025 in “Marine Drugs” This study evaluated a new composite material made from PLA, ALG, ZnS, and HT for blood-contacting applications, finding it improved surface characteristics and displayed anticoagulant properties and high biocompatibility with no genotoxic effects on blood and skin cells.
August 2025 in “ACS Omega” This study synthesized and evaluated hydroxycinnamate derivatives for their ability to inhibit human SRD5A1, finding that three compounds showed significant inhibitory activity and low cytotoxicity. Compound 10a notably reduced SRD5A1 protein expression in cells, suggesting potential for nonsteroidal treatment of androgen-related conditions.
August 2025 in “Acta Biomaterialia” This study presents a novel hydrogel scaffold made from tilapia collagen, which when activated by ultrasound, reprograms macrophages to promote wound healing, enhance angiogenesis, and stimulate hair follicle regeneration, offering a potential new method for treating inflammatory wounds.
August 2025 in “International Journal of Nanomedicine” This review discusses metal-organic frameworks for treating diabetic infected wounds and related applications, reporting no new clinical results but highlighting challenges like biosafety and production for future research.
January 2025 in “Nanoscale” This study reports that a new boron/nitrogen-doped carbon nano-onion-based delivery system for doxorubicin enhanced its uptake and anticancer effects in specific cancer cell types, while reducing cardiotoxicity in human heart cells.
December 2024 in “Pharmaceutics” This review systematically examined recent advancements in spironolactone-loaded nanocarriers, revealing that lipid and vesicular nanoparticles enhance bioavailability and skin penetration for treating androgen-dependent disorders, but highlighted the need for further clinical studies to optimize their use.
June 2024 in “International Journal of Nanomedicine” This review outlines recent progress in CRISPR/Cas9 genome editing, discussing its structure, mechanisms, and the use of genetic, chemical, and physical strategies to enhance precision and reduce off-target effects despite some persistent challenges for clinical application.
February 2024 in “Medicina” In this study, researchers used atomic force microscopy to capture and analyze morphological changes in the surface of healthy hair, identifying features such as pitting and rod-shaped macro-fibrillar elements, which could inform future research on hair conditions and care.
January 2024 in “Advanced Science” In this study, researchers used a chemical cocktail and hydrogel microspheres to successfully guide fibroblasts into dermal papilla cells, promoting wound healing and in situ hair follicle regeneration while reducing scar formation, in both in vitro and in vivo experiments.
January 2024 in “Materials chemistry frontiers (Online)” This study reviews recent advancements in near-infrared organic light-emitting diode (NIR OLED) technologies, focusing on their applications and the diverse luminescent materials used in their emissive layers.
January 2024 in “Biochemistry Research International” This study found that compounds from Ziziphus spina-christi roots exhibited promising antibacterial and antioxidant activities, supporting its traditional medicinal use.
December 2023 in “The journal of physical chemistry. B (1997 : Online)” This study explored the potential of human hair keratin as a filtration material, finding that it may effectively absorb the pollutants diclofenac and perfluorobutanesulfonate. The researchers reported significant binding affinities through molecular simulations, supporting further investigation into keratin's use for water purification.
August 2023 in “International Journal of Molecular Sciences” This review highlights that liposomes offer a promising method for delivering CRISPR/Cas9 components for precise and efficient genetic modifications, with potential applications in correcting genetic diseases and enhancing immune cell function.
9 citations
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January 2023 in “Langmuir” This study presents a method for directly measuring the solubility of solid chemicals in the skin's stratum corneum under various humidity conditions, emphasizing its importance for dermal drug delivery and chemical safety assessments.
13 citations
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March 2006 in “International Journal of Cosmetic Science” The study found that a polymer treatment changes the charge on hair surfaces, making bleached hair smoother and less porous.
1 citations
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February 2015 in “Zenodo (CERN European Organization for Nuclear Research)” This study tested five different brands of hair building fibers, examining their electrostatic and dielectric properties as well as analyzing their fiber structure with scanning electron microscopy.
27 citations
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July 1990 in “International Journal of Dermatology” In this controlled study, a pulsed electrical field treatment significantly increased hair regrowth compared to baseline and the control group over 36 weeks, without observed side effects.
42 citations
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January 2009 in “Colloids and Surfaces B: Biointerfaces” This study found that dimethylpabamidopropyl laurdimonium tosylate, a quaternary ammonium surfactant, adsorbs onto human scalp hair with kinetic and isotherm behaviors fitting specific models, changing hair fiber wettability from hydrophobic to hydrophilic.
29 citations
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August 2005 in “Biopolymers” In this study, researchers found that L-cysteine interacted electrostatically with anionic ions on the surface of keratin fibers in human hair, reducing the rate of disulfide bond disconnection at pH 9.0.
22 citations
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October 1996 in “Dermatologic clinics” This review summarizes recent advances in understanding intermediate filament structure and their implications for pathological mutations and human diseases, but it reports no new experimental results.
17 citations
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January 2023 in “International Journal of Cosmetic Science” In this study, hydrophobic interactions were found to primarily drive deposition on virgin hair, while electrostatic interactions were more significant for bleached hair, highlighting different target moieties for hair conditioning products.
14 citations
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January 2012 in “Proteins” This study's molecular dynamics simulations suggest that electrostatic interactions mainly stabilize peptide binding to human hair keratin, with the protein's dielectric constant significantly affecting free energy calculations.
6 citations
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December 2013 in “Journal of Cosmetic Dermatology” This article reviews the use of pigmented concealing powders as a viable cosmetic option for patients with alopecia, noting the potential for a more natural appearance compared to traditional hairstyling or hairpieces, but it presents no new clinical results.
5 citations
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April 2018 in “Chem” This study introduced a novel graphene-based hair dye that is non-reactive, non-invasive, and eliminates toxic chemicals, while providing durable color, antistatic properties, and efficient heat dissipation, even after 30 washes.
2 citations
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June 2023 in “Pharmaceutics” This study systematically reviews the development and applications of drug-loaded nanofiber scaffolds in wound healing, highlighting challenges such as maintaining drug activity and achieving controlled release, while summarizing preparation methods and describing advanced drug delivery schemes.
2 citations
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July 2012 in “PubMed” In this study, the use of internal wool lipid liposomes was shown to improve the lipid composition and increase the resistance to breaking in both untreated and chemically treated hair fibers.
1 citations
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December 2007 in “Journal of Microbiology and Biotechnology” This study found that Minoxidil included in triamino alpha-cyclodextrin significantly promoted hair growth in mice, potentially due to its enhanced substantivity on skin.
April 2026 in “Applied Materials Today” This study introduced a pH-responsive polymeric wound dressing that enhances healing in chronic wounds by changing shape and drug delivery based on wound pH, achieving a 94.88% healing rate in diabetic mice by day 14.