December 2025 in “Frontiers in Medicine” This review details the global mutation patterns of genes associated with autosomal recessive woolly hair/hypotrichosis and highlights potential, yet unproven, treatments like minoxidil and regenerative therapies, reporting no new clinical results.
August 2024 in “Journal of Animal Science and Technology” This study identified specific keratin-associated protein genes that are highly expressed in different varieties and sexes of Angora goats, providing insights for improving mohair development through targeted breeding strategies.
This study examined the molecular communication in psoriasis cells, highlighting unique immune cell interactions and identifying new features of the hair follicle cell-psoriasis axis. It suggests the potential for targeted therapies at the single-cell level to improve psoriasis treatment.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that AP-2α and AP-2β transcription factors are crucial for maintaining adult skin homeostasis, with their inactivation in keratinocytes leading to impaired differentiation, hair abnormalities, and inflammation, highlighting their key regulatory roles.
May 2023 in “Research Square (Research Square)” This study found that the natural product Shi-Bi-Man significantly promoted hair regeneration in cynomolgus monkeys, increasing hair follicle number and activation by boosting specific protein markers and interactions in Laminin-related pathways.
August 2022 in “Frontiers in genetics” This study identified a novel bi-allelic missense variant in the DSC3 gene linked to severe Hypotrichosis with Recurrent Skin Vesicles in a Saudi child, supporting its role in the condition.
This thesis found that desmoplakin mutations in cardiocutaneous syndrome are linked to dose-dependent disease severity and identified mechanisms by which KLHL24 mutations cause cardiomyopathy, with rescue experiments successfully preventing this phenotype in patient-derived heart tissues.
May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that hair-type tissues in hedgehogs show higher enrichment of immune-related genes compared to spine-type tissues, suggesting that spines evolved to protect against injuries and infections.
February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that Prss53-mutated rabbits exhibited curved hair and skeletal dyskinesia, suggesting a link between Prss53 loss and these traits, potentially involving disrupted calcium metabolism.
January 2016 in “Research Explorer (The University of Manchester)” Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.
April 2024 in “Research Square (Research Square)” This study found that bioconjugating 16-methylheptadecanoic acid (16-MHA) to damaged hair can mimic the protective properties of 18-methyleicosanoic acid (18-MEA), restoring the hair's structural integrity and moisture homeostasis, even after washing.
7 citations
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April 2018 in “Cosmetics” This study found that the medulla of Japanese hair contains unsaturated lipids such as squalene and oleic acid, which may contribute to hair glossiness.
October 2021 in “Meditsinskiy sovet = Medical Council” This study found that cyproterone acetate treatment improved quality of life and reduced anxiety and depressive symptoms in women with skin manifestations of hyperandrogenism.
8 citations
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June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study provides definitive evidence that a homozygous mutation in the DSC3 gene causes skin fragility and hypotrichosis in humans.
November 2025 in “Stem Cell Research & Therapy” This study suggests that human DSCCs may aid in hair follicle regeneration and reduce microinflammation, with potential applications in regenerative medicine evaluated through a new morphometric analysis.
1 citations
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January 2025 in “Advances in Wound Care” This study identified dual epithelial and mesenchymal traits in dermal sheath cells during wound repair, suggesting they could be targeted to enhance healing.
96 citations
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September 1996 in “PubMed” This study demonstrated that murine monoclonal antibodies can reveal specific patterns of desmosomal cadherin expression, Dsc1 and Dsc3, in human tissues and cultured cells using immunofluorescence microscopy.
December 2018 in “Dermatologic Surgery” This overview describes the Dermatologic Surgery journal's comprehensive focus on cosmetic and reconstructive skin procedures, but it reports no new research findings.
September 2012 in “대한피부과학회지” In this study, Dsc 1 was highly expressed in certain layers of fetal epidermis and hair follicle but not in basal cells or oral mucosa, indicating its potential role in maintaining epithelial integrity.
April 2023 in “Journal of Investigative Dermatology” This study found that autologous cell-based therapy using dermal sheath cup cells showed a moderate increase in hair volume in patients with pattern hair loss, particularly in women.
1 citations
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May 2026 in “Nature Communications” This study demonstrated that CD19-CAR T cell therapy may promote structural regeneration in the skin of systemic sclerosis patients, as evidenced by histological improvements and fibroblast population changes, suggesting its potential for tissue remodeling in fibrotic diseases.
13 citations
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July 2014 in “The Journal of Dermatology” Dermoscopy helped diagnose discoid lupus erythematosus in two patients without needing skin biopsies.
November 2023 in “Journal of Dermatological Science” This study found that ITGA6-positive dermal sheath cup cells, identified by their superior migratory activity, may enhance cell-based therapy for male and female pattern hair loss by promoting cell migration into hair follicles.
3 citations
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August 2024 in “Cureus” This study found that DALL-E 2 performed poorly in generating accurate images of most pediatric dermatological conditions, highlighting the need for more domain-specific and inclusive training data.
January 2018 in “Journal of Investigative Dermatology” This quiz article provides a series of dermatological diagnosis questions based on a Journal of Investigative Dermatology article and includes explanations but reports no original research findings.
2 citations
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June 2022 in “International Journal of Molecular Sciences” This study found variable outcomes in hair loss treatment with autologous cell-based therapy using DSC cells, with certain gene markers showing inconsistent correlations with treatment efficacy.
822 citations
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January 2021 in “Genome biology” This study presents a new method called scMC that effectively distinguishes biological from technical variation in single-cell genomics datasets, demonstrating its ability to accurately align and detect biological signals across various experiments.
61 citations
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March 2009 in “The Journal of the American Board of Family Medicine” This article reviews current diagnostic and treatment approaches for discoid lupus erythematosus, emphasizing the importance of early treatment and photoprotection, but reports no new clinical findings.
47 citations
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August 2016 in “American Journal Of Pathology” This study reports that in systemic sclerosis, CD34+ dermal fibroblasts transition to CD34−, podoplanin+, and CD90+ fibroblasts across the dermis, suggesting a role in unchecked fibrosis.
195 citations
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November 2001 in “The Journal of Cell Biology” This study found that desmocollin 1 is crucial for strong adhesion and barrier maintenance in the mouse epidermis, with its absence leading to skin and hair issues resembling chronic dermatitis.