Biomimetics Through Bioconjugation of 16-Methylheptadecanoic Acid to Damaged Hair for Hair Barrier Recovery

    April 2024 in “ Research Square (Research Square) ”
    Sang-Hun Song, H.-S. Park, Byung Tack Lim, Seong Kil Son
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    TLDR 16-MHA can restore the barrier and moisture of damaged hair, making it similar to undamaged hair.
    The study investigates the use of 16-methylheptadecanoic acid (16-MHA) as a biomimetic substitute for 18-methyleicosanoic acid (18-MEA) to restore the lipid barrier of damaged hair. After confirming the removal of 18-MEA from hair using X-ray photoelectron spectroscopy (XPS), 16-MHA was synthesized and bioconjugated to the hair via a carbodiimide reaction. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) showed that 16-MHA remained on the hair surface even after washing. Differential scanning calorimeter (DSC) analysis and moisture content evaluation indicated that hair treated with 16-MHA exhibited physical properties similar to undamaged hair, suggesting that this method effectively restores both the structural integrity and moisture balance of damaged hair.
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