Biomimetics Through Bioconjugation of 16-Methylheptadecanoic Acid to Damaged Hair for Hair Barrier Recovery

    April 2024 in “ Research Square (Research Square) ”
    Sang-Hun Song, H.-S. Park, Byung Tack Lim, Seong Kil Son
    Image of study
    TLDR 16-MHA can restore the barrier and moisture of damaged hair, making it similar to undamaged hair.
    The study investigates the use of 16-methylheptadecanoic acid (16-MHA) as a biomimetic substitute for 18-methyleicosanoic acid (18-MEA) to restore the lipid barrier of damaged hair. After confirming the removal of 18-MEA from hair using X-ray photoelectron spectroscopy (XPS), 16-MHA was synthesized and bioconjugated to the hair via a carbodiimide reaction. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) showed that 16-MHA remained on the hair surface even after washing. Differential scanning calorimeter (DSC) analysis and moisture content evaluation indicated that hair treated with 16-MHA exhibited physical properties similar to undamaged hair, suggesting that this method effectively restores both the structural integrity and moisture balance of damaged hair.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 678 results

      community 16 months finasteride & minoxidil progress

      in Progress Pictures  608 upvotes 4 months ago
      User shared 16-month progress using finasteride 1 mg/day and minoxidil 5% solution once/day, noting significant regrowth, especially in temporal peaks. Users discussed shedding, side effects, and positive feedback from others.

      community 16 months or so. Back from the dead. Age 41

      in Progress Pictures  555 upvotes 5 months ago
      A user shared their 16-month hair regrowth progress using oral and topical minoxidil, dutasteride, derma rolling, and occasional keto shampoo. The conversation includes positive reactions and jokes about their impressive results.

      community 16, female, losing a ton of hair

      in Female  6 upvotes 6 months ago
      A 16-year-old female experiencing severe hair loss and sebum buildup, likely due to telogen effluvium and PCOS, is currently using vitamin D3 supplements, Redenser serum, and T follihair supplements. Recommendations include addressing PCOS first and consulting a doctor.

      community 16 months of Fin (M47). 1mg 3x per week.

      in Progress Pictures  156 upvotes 6 months ago
      A 48-year-old man shared his 16-month hair regrowth journey using finasteride 1mg three times a week, noting some regrowth and emphasizing patience. He chose not to use it daily to minimize side effects, and while some users debate the effectiveness, he confirms maintenance and possibly some regrowth.

      community Dutasteride 16 weeks in (losing small hairs only)

      in Finasteride/Dutasteride  11 upvotes 6 months ago
      The conversation discusses hair loss where only short, thin hairs are being shed after 16 weeks of using dutasteride, with no visible regrowth. One response suggests that shedding short hairs is a positive sign, indicating that the hair follicles are still active and responding to treatment.

      community Diagnosed with MPB at 16 (Male)

      in Treatment  54 upvotes 6 months ago
      A 16-year-old diagnosed with male pattern baldness (MPB) was prescribed hair vitamins, vitamin D, a non-ketoconazole shampoo, and redenysl + serum, with a suggestion for GFC or IHRF treatments. Some users recommended minoxidil, ketoconazole, and derma stamping, while others advised against certain treatments until the age of 18.

    Similar Research

    5 / 1000+ results