Biomimetics Through Bioconjugation of 16-Methylheptadecanoic Acid to Damaged Hair for Hair Barrier Recovery

April 2024 in “ Research Square (Research Square) ”

Sang-Hun Song, H.-S. Park, Byung Tack Lim, Seong Kil Son

16-methylheptadecanoic acid 16-MHA 18-methyleicosanoic acid 18-MEA bioconjugation lipid barrier damaged hair X-ray photoelectron spectroscopy XPS carbodiimide reaction Time-of-flight secondary ion mass spectrometry TOF-SIMS Differential scanning calorimeter DSC moisture content evaluation

TLDR 16-MHA can restore the barrier and moisture of damaged hair, making it similar to undamaged hair.

The study investigates the use of 16-methylheptadecanoic acid (16-MHA) as a biomimetic substitute for 18-methyleicosanoic acid (18-MEA) to restore the lipid barrier of damaged hair. After confirming the removal of 18-MEA from hair using X-ray photoelectron spectroscopy (XPS), 16-MHA was synthesized and bioconjugated to the hair via a carbodiimide reaction. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) showed that 16-MHA remained on the hair surface even after washing. Differential scanning calorimeter (DSC) analysis and moisture content evaluation indicated that hair treated with 16-MHA exhibited physical properties similar to undamaged hair, suggesting that this method effectively restores both the structural integrity and moisture balance of damaged hair.

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