Protein Disulfide Isomerase-Mediated Grafting of Cysteine-Containing Peptides onto Over-Bleached Hair

    December 2011 in “ Biocatalysis and biotransformation ”
    Margarida M. Fernandes, Artur Cavaco‐Paulo
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    TLDR PDI helps restore over-bleached hair's strength and structure by attaching special peptides.
    The study investigated the use of Protein disulphide isomerase (PDI) to graft cysteine-containing peptides onto over-bleached hair to restore its properties. Peptides based on human keratin and lung surfactant proteins, linked to a fluorescent dye, were used to assess penetration and effectiveness. After eight bleaching treatments, hair showed 42% less mechanical resistance and decreased α-helix denaturation properties. PDI facilitated peptide attachment and penetration into the hair cortex, improving mechanical and thermal properties, including increased α-helix denaturation enthalpy, Young's modulus, and tensile strength. The peptide treatment with PDI showed promise for hair-care applications.
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