research The Paradox of p53: What, How, and Why?
The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
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research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor
LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.
research Quantification of the Vitamin D Receptor-Coregulator Interaction
Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.
research Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function
Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.
research The Hair Follicle as an Estrogen Target and Source
Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer
Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.
research FOXO1, TGF-β Regulation and Wound Healing
FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.
research The Role of Nuclear Hormone Receptors in Cutaneous Wound Repair
Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.
research Which Chemicals Should Be Grouped Together for Mixture Risk Assessments of Male Reproductive Disorders?
Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.
research The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications
Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.
research Hereditary Vitamin D Rickets: A Case Series in a Family
Three siblings with a genetic form of rickets showed different symptoms of the disease.
research Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia
Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.
research Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism
Vitamin D receptor may help protect against UV-induced skin cancer.
research Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp
Hair greying is linked to reduced ATM protein in hair cells, which protects against stress and damage.
research Prolonged Use of Finasteride-Induced Gonadal Sex Steroids Alterations, DNA Damage, and Menstrual Bleeding in Women
Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.
research Androgens and Hair Growth
Androgens can both increase and decrease hair growth in different parts of the body.
research Clock Genes, Hair Growth, and Aging
Circadian clock genes are important for hair growth and may affect aging-related hair loss and graying.
research Auxin And Ethylene: Collaborators Or Competitors?
Auxin and ethylene hormones both work together and against each other to control plant growth.
research Circadian Clock-Mediated Control of Stem Cell Division and Differentiation: Beyond Night and Day
The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.
research Circadian Clocks: From Stem Cells to Tissue Homeostasis and Regeneration
Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.
research Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers
The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.
research Growing an Epidermal Tumor
The glucocorticoid receptor helps protect skin from tumors and other issues.
research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.
research Skin Cancer: Understanding the Transformation from Conventional to Advanced Treatment Approaches
New treatments like nanotechnology show promise in improving skin cancer therapy.
research SnapshotDx Quiz: August 2019
The research found that male pattern hair loss is mostly genetic and involves hair thinning due to hormonal effects and changes in gene expression.
research Cell Death in the Skin: Mechanisms and Implications
Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.
research Estrogens and Aging Skin
Estrogen therapy can reduce skin aging but has cancer risks.
research Revising the Role of the Androgen Receptor in Breast Cancer
The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.
research Androgen Receptor Mutations and Polymorphisms in African American Prostate Cancer
African American men with prostate cancer have more androgen receptor mutations, which may lead to more aggressive cancer compared to Caucasian American men.
research New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today's Pre-Clinical Data into Tomorrow's Daily Clinical Practice
New treatments for skin conditions related to the sebaceous gland are being developed based on current research.