33 citations
,
May 1984 in “Journal of Pharmacy and Pharmacology” This study found that while systemic absorption of DHT from liposomes was negligible, the topical biological effect was weaker compared to DHT dissolved in acetone on the female hamster flank organ model.
7 citations
,
June 2000 in “Journal of the American Academy of Dermatology” This study found that betamethasone valerate in a foam vehicle has comparable total coverage to traditional topical corticosteroid vehicles, despite less coverage per unit of foam.
July 2026 in “Journal of Drug Delivery Science and Technology”
23 citations
,
April 1991 in “Journal of The American Academy of Dermatology” Minoxidil solution can cause skin irritation and allergies in some users.
October 2023 in “Jurnal Ilmu Kesehatan Hewan” This report describes the successful treatment of dermatophytosis due to Trychophyton spp. in a 2-month-old kitten using ketoconazole cream, fish oil, multivitamin syrup, and sulfur soap, resulting in significant improvement in the skin condition after four weeks.
22 citations
,
November 2018 in “Brazilian Journal of Pharmaceutical Sciences” This review discusses iontophoresis, low-frequency ultrasound, and microneedles for enhancing topical drug delivery in dermatological treatments and reports no clinical results; it emphasizes their mechanisms and potential uses.
July 2023 in “International journal of advanced research in medical and pharmaceutical sciences” In this study, researchers formulated and evaluated a gel containing minoxidil and aloe vera for alopecia treatment, finding that it was stable and non-irritant on albino rats, suggesting enhanced topical drug delivery over traditional solutions.
11 citations
,
October 1990 in “The Journal of dermatologic surgery and oncology” This review discusses the potential for new retinoids, topical antiandrogens, and alternative therapies to surpass tretinoin in treating cutaneous aging, but reports no clinical results.
11 citations
,
July 1984 in “Australian Veterinary Journal” This study found that povidone iodine, thiabendazole ointment, captan ointment, and Burroughs Wellcome Ringworm Ointment were effective against Trichophyton equinum var. autotrophicum in horses, but large-scale use may be limited by practicality and cost.
1 citations
,
November 2023 in “Journal of Innovations in Applied Pharmaceutical Science (JIAPS)” In this study, researchers developed a neem oil-based emulgel showcasing anti-dandruff properties with controlled dual release, observing formulation F5 providing a 65.27% release after 8 hours and the highest antifungal inhibition against Candida albicans.
July 2026 in “International Journal of Advanced Biochemistry Research” This study found that a herbal spray for treating bovine dermatophytosis was safe and economical, though conventional antifungal therapy had a higher cure rate.
December 2025 in “MEDFARM Jurnal Farmasi dan Kesehatan” This review evaluates existing research on topical metformin for skin conditions, reporting promising outcomes such as improved wound healing, melasma, psoriasis, acne, and alopecia, with innovative formulations like hydrogels and lipid nanoparticles enhancing its cutaneous delivery while minimizing systemic exposure.
January 2024 in “Figshare” This study concluded that an ointment containing pine turpentine oil, larch turpentine, and eucalyptus oil was an effective and safe treatment for folliculitis, showing improvement over placebo in lesion evolution, responder rate, and patient assessment.
This study observed that 2% minoxidil solution stopped hair loss and promoted new hair growth in 85% of female pattern androgenetic alopecia patients, while 2% progesterone solution achieved similar results in 71% of patients.
February 2024 in “PubMed” This study reported that minoxidil lotions produced using a propylene glycol-free base, Aloplus Total, demonstrated high minoxidil solubility and maintained chemical and physical stability for over 180 days, suggesting suitability for enhanced topical treatments of androgenetic alopecia.
November 2025 in “Journal of Medicinal Chemistry” This review outlines advances in topical PROTACs for localized protein degradation, focusing on AH-001 and GT20029 for skin conditions, but presents no new clinical trial results.
July 2023 in “GLOBAL JOURNAL FOR RESEARCH ANALYSIS” This study explored a new treatment approach using 20% TCA application with topical bimatoprost solution for managing alopecia areata of the eyebrows in cases where traditional treatments failed, offering a potential additional option for difficult cases.
9 citations
,
January 2013 in “BioMed research international” This article suggests targeting the water activity within pilosebaceous follicles using biocompatible solutes like xylose and sucrose as a new potential topical treatment for acne.
September 2023 in “International Journal of Applied Pharmaceutics” This study found that a topical gel containing Minoxidil and Tofacitinib citrate showed promise for treating alopecia areata, with formulation F5 demonstrating effective drug release and stability in evaluations.
11 citations
,
January 2014 in “Open journal of veterinary medicine” In these clinical cases, topical propolis treatment effectively resolved canine dermatophytosis, including hair regrowth, with no known side effects, suggesting it as a promising natural treatment option.
February 2022 in “Scientia Pharmaceutica” This study validated that six out of seven tested topical formulations for alopecia are compatible for 6-month use, suggesting they may be practical for compounding pharmacies.
1 citations
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February 2015 in “Journal of evolution of medical and dental sciences” This study concluded that 0.05% betamethasone dipropionate cream is more effective than other topical treatments for improving alopecia areata over 12 weeks.
January 2024 in “Figshare” This study suggests that a turpentine ointment may be an effective and safe treatment for acute folliculitis, as it showed improvements over placebo in lesion evolution, responder rate, and patient assessments.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study developed a low-viscosity triamcinolone acetonide serum, used with a derma stamp microneedling device, to improve targeted treatment of alopecia areata, reporting favorable drug solubility, spreadability, and permeation to hair follicles, while maintaining skin safety.
7 citations
,
October 2018 in “Dermatology practical & conceptual” This study found that topical oxygen therapy may be a beneficial adjuvant treatment for hair loss, acne, and chronic dermatological conditions, though further research is needed to confirm its effectiveness.
188 citations
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October 2012 in “The AAPS Journal” This review discusses strategies for developing semi-solid topical generic products to match the quality of reference-listed drugs, using concepts like quality by design and reverse-engineering, but reports no new results.
19 citations
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March 2011 in “Cutaneous and Ocular Toxicology” Some chemicals absorbed through the skin can cause serious health problems.
23 citations
,
July 2008 in “British journal of dermatology/British journal of dermatology, Supplement” This review discusses the use of contact sensitizers for topical immunotherapy in dermatological conditions such as alopecia areata and viral warts, but it reports no new clinical findings.
1 citations
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July 2005 in “CRC Press eBooks” This paper discusses topical drug delivery targeting the pilosebaceous unit for skin diseases and cosmetic purposes, emphasizing formulation choice and drug physicochemical properties but reports no new findings.
39 citations
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January 2012 in “International Journal of Trichology” This study found that topical melatonin solution was associated with positive effects on hair density and reduction in hair loss for androgenetic alopecia, with good tolerability reported in several clinical trials.