Formulation and Evaluation of Minoxidil Gel with Aloe Vera for Topical Treatment of Alopecia

July 2023 in “ International journal of advanced research in medical and pharmaceutical sciences ”

Reddy Madhavi, G. Bhavani, R Renuka, Vanam Kavya sri, Md. Kausar Alam, Pulak Ranjan Mahata, Shaik Shabber, K. N. Venkateshwar Rao

minoxidil Aloe vera alopecia carbopol 940 HPMC topical gel scalp hair growth skin irritation Rogaine Aloe hair loss thickener gel

TLDR The gel combining minoxidil and Aloe vera could be an effective, non-irritating treatment for hair loss.

The study investigated a topical gel combining minoxidil and Aloe vera for treating alopecia, aiming to enhance the drug's contact time and concentration on the scalp. Various gel formulations were created using carbopol 940 and HPMC as thickeners, with Aloe vera added for its soothing and hair growth-promoting properties. The gels underwent evaluation for appearance, pH, spreadability, and skin irritation in albino rats. The results indicated that the formulation labeled F5, which included carbopol, HPMC, and Aloe vera, was optimal regarding stability, non-irritation, and ease of application. The study suggests that this gel could be an effective and moisturizing treatment for alopecia, potentially reducing the side effects commonly associated with minoxidil use, and offering a more efficacious therapeutic alternative.

View this study on ijarmps.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community New hack? Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

in Research/Science 17 upvotes 2 years ago

The conversation discusses how Tretinoin may improve the effectiveness of Minoxidil for treating hair loss by increasing the activity of certain enzymes in hair follicles. One user comments that this information is not new.

community Suspicious about my dermatologist

in Product 10 upvotes 5 months ago

A 17-year-old is concerned about hair loss and questions his dermatologist's advice against using finasteride due to age. The dermatologist recommended a serum with aloe vera, saw palmetto, biotin, and dexpanthenol, but the user is skeptical and considers using minoxidil instead.

community Caffeine & Alopecia: What the Science Seems to Say

in Research/Science 17 upvotes 1 year ago

The conversation discusses the potential benefits of topical caffeine for Androgenetic Alopecia (APA) and female pattern hair loss. While some studies suggest positive results, there's no reliable scientific evidence to strongly recommend caffeine compounds for hair regrowth.

community If DHT is the one big primary reason for Hairloss.. Then other reasons are hoax?

in Chat 8 upvotes 2 years ago

The conversation discusses various theories and suggestions for hair loss, with a focus on DHT as the primary cause. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community 1.5 years fin plus almost 3 years min, I think I’ve definitely made progress but I’m still not where I want to be, advice?

in Progress Pictures 130 upvotes 11 months ago

The user has been using finasteride for 1.5 years and minoxidil for almost 3 years for hair loss, and has seen some maintenance of hair but not significant regrowth. Suggestions from others include switching to dutasteride, trying oral minoxidil, and considering microneedling or hair fibers for better appearance.

community Huge holes on donor area of scalp is this even normal?

in Transplants 106 upvotes 1 year ago

The conversation is about a person experiencing significant hair loss in the donor area after a hair transplant, with others suggesting it might be shock loss. The person is taking oral minoxidil and dutasteride to help with the issue.

Related Research

1 / 1 results

research Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment

14 citations, January 2015 in “Skin appendage disorders”

Minoxidil treatment for hair loss can cause scalp allergy and severe hair loss.