Design and Characterization of Topical Emulgel Containing Neem Oil for Its Anti-Dandruff Properties

November 2023 in “ Journal of Innovations in Applied Pharmaceutical Science (JIAPS) ”

Eby George, Dhanish Joseph, Abitha N Jabbar, Khansa Beegam M A, Nimisha Joseph, M. Prince Francis, Anju Boban, Ann Maria Alex

neem oil emulgel carbopol-934 antidandruff Candida albicans antifungal non-fickian diffusion

TLDR The neem oil emulgel effectively treats dandruff and is easy to use on the scalp.

The study developed and characterized a topical emulgel containing neem oil for its anti-dandruff properties. Five formulations were prepared using the polymer carbopol-934, with formulation F5 showing the highest efficacy. The emulgel demonstrated a 65.27% release of neem oil after 8 hours in vitro and exhibited a significant antifungal effect against Candida albicans, with a zone of inhibition of 12 mm. The emulgel formulation offers advantages such as controlled dual release, optimal spreadability, stability, aesthetic appearance, and adherence to the scalp, with a pH similar to that of the scalp.

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