2 citations
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November 2004 in “Hospital pharmacy” This article reviews adverse drug reactions, emphasizes methods of prevention, and encourages reporting to the FDA's medWatch program, but presents no new study findings.
10 citations
,
October 2016 in “Epilepsy & behavior” In this study, behavioral disturbances were commonly observed with levetiracetam, while somnolence was frequently reported with oxcarbazepine among patients with refractory epilepsy.
16 citations
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October 2004 in “Acta dermato-venereologica” This article provides information about the University of Bologna's departments involved and includes contact details for the lead author, but it presents no research findings.
This study suggests that 5alpha-dihydroprogesterone could be an effective, non-sedative anticonvulsant for drug-resistant complex partial seizures, as observed in a rat model.
41 citations
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December 2008 in “Journal of the American Academy of Dermatology” This review discusses fixed drug eruption (FDE) potentially linked to finasteride and emphasizes dermatologists' need to recognize its possible occurrence due to the drug's widespread use, but reports no new clinical results.
9 citations
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May 2001 in “Journal of the American Veterinary Medical Association” This case report describes a cat that developed alopecia and hyperactivity after ingesting valproic acid from contaminated household food, with symptoms resolving after the drug was removed.
19 citations
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December 1999 in “International Journal of Dermatology” This case report diagnosed variegate porphyria in a 33-year-old woman based on significant laboratory abnormalities, but with clinical features resembling porphyria cutanea tarda.
7 citations
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May 2021 in “Seizure” This review found that antiseizure medications, particularly phenytoin and valproate, are associated with cosmetic side effects like gingival hyperplasia, hirsutism, acne, and hair loss.
26 citations
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November 2016 in “European Journal of Clinical Pharmacology” This study found that using valproic acid during radiotherapy for glioma was associated with delayed hair loss and improved survival outcomes.
July 2014 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Applying valproic acid on the scalp increased hair growth in men with hair loss.
12 citations
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May 2005 in “Journal of the American Geriatrics Society” This case report describes successful treatment of valproate-induced hyperammonemia in a 79-year-old man using lactulose, marking the first such documented use for this condition.
January 2022 in “Elsevier eBooks” This study found that sodium valproate nanospanlastics could be an effective and safer method for treating androgenic alopecia, with results comparable to minoxidil but fewer side effects.
January 2024 in “Archives of dermatological research” In this clinical study, researchers reported that both sodium valproate-loaded nanospanlastics and topical corticosteroids showed comparable modest efficacy in treating patchy alopecia areata, recommending further investigation into sodium valproate's role combined with other therapies.
7 citations
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September 2017 in “Pharmacoepidemiology and Drug Safety” This study observed a strong overall reduction in the use of CPA/EE in the Netherlands, despite similar proportions of users with acne or other hyperandrogenic conditions before and after the referral procedure.
This abstract details known indications, categories, and potential reactions for various drugs, including anorexiants, estrogens, NSAID analgesics, cardiac glycosides, and migraine preventives, without reporting new clinical results.
January 2023 in “The Egyptian Journal of Hospital Medicine” This study found that topical valproic acid and 5% minoxidil both significantly increased hair count in patients with female pattern hair loss, suggesting topical valproic acid as a potential treatment option.
5 citations
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August 2018 in “European Psychiatry” In this large multicenter study, severe hair loss related to psychotropic drug treatment was very rare but occurred more frequently in female patients, with valproic acid showing the highest risk.
July 2023 in “Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ” The research investigated the effects of antiandrogens on neurodevelopmental milestones in rats exposed to valproic acid during pregnancy, finding that while valproic acid delayed sensorimotor reflexes, it didn't impact physical development milestones, and antiandrogens partially mitigated these delays.
May 2022 in “Indian Journal of Pharmacology” This case report highlights a rare instance of valproate-induced hypertensive urgency in a 2-year-old girl, with improvement after stopping the medication.
16 citations
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March 1986 in “Biochemical Pharmacology”
16 citations
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August 2014 in “International Journal of Women's Health” The estradiol valerate/dienogest oral contraceptive helps with heavy periods, may improve acne and symptoms in PCOS, and doesn't affect sexual function.
60 citations
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December 2013 in “PLoS ONE” The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.
10 citations
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January 2020 in “Acta Neurobiologiae Experimentalis” This study found that valproic acid and crocin, alone or together, significantly increased the expression levels of neurotrophic factors in rat-derived epidermal neural crest stem cells, suggesting therapeutic potential for neurological disorders.
38 citations
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November 2005 in “Epilepsia” This study discusses levetiracetam's role as an alternative treatment for idiopathic generalized epilepsies, highlighting its potential effectiveness, especially for patients unsuitable for valproate.
13 citations
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February 2013 in “BMJ Case Reports” This case report suggests that discontinuing finasteride, which may affect neurosteroids synthesis, improved seizure control in a woman with temporal lobe seizures.
13 citations
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November 2005 in “Epilepsia” This study suggests that the anticonvulsant effects of deoxycorticosterone in young rats may be mediated by its metabolites and interactions with multiple receptors, including mineralocorticoid and progesterone receptors.
May 2024 in “Reactions weekly” 8 citations
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April 2022 in “International Journal of Environmental Research and Public Health” This study found that pediatric epilepsy patients on polytherapy experienced more adverse drug reactions compared to those on monotherapy, despite improved seizure control with polytherapy.
May 2025 in “Reactions Weekly” 29 citations
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October 2009 in “Pharmacology Biochemistry and Behavior”