July 2018 in “Elsevier eBooks” This study reviews drug-induced hair changes, noting that hair loss often reverses after stopping the drug, but permanent alopecia cases post-chemotherapy are rising.
January 2009 in “Side effects of drugs annual” This study observed no teratogenic effects of oral decongestants and surprisingly favorable neonatal outcomes in Swedish women who used them during pregnancy.
October 2008 in “Clin-alert” This abstract lists keywords related to various medications and therapies, but it does not provide new study results or findings.
5 citations
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January 2016 in “Clinical psychopharmacology and neuroscience/Clinical Psychopharmacology and Neuroscience” This report discusses that curly hair is a very rare side effect of valproate, a medication used as a mood stabilizer for bipolar disorder, though such drug-induced hair changes are uncommon.
37 citations
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February 2014 in “Journal of Dermatology” This study found that topical valproic acid significantly increased hair count in male patients with moderate androgenetic alopecia compared to placebo over 24 weeks.
January 2025 in “Dusunen Adam The Journal of Psychiatry and Neurological Sciences”
January 2024 in “Authorea (Authorea)” This study found that Sudanese epilepsy patients prioritize medication intake despite cosmetic effects from antiepileptic drugs, which may be influenced by cultural perceptions unique to the population.
36 citations
,
October 2008 in “European journal of paediatric neurology” This study found that pediatric patients on valproic acid may experience hair loss due to reduced zinc and biotinidase levels within the first 3 months, with zinc depletion continuing to contribute by the 6th month.
28 citations
,
July 2017 in “Journal of Endocrinological Investigation” This study suggests that early onset androgenetic alopecia in men may indicate a male PCOS equivalent, possibly leading to higher risks of metabolic and cardiovascular disorders later in life.
5 citations
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August 2017 in “The Journal of Clinical Psychiatry” In this letter, excessive hair loss due to telogen effluvium was observed as a distressing side effect in the early months of valproate treatment, potentially linked to disruption in biotin metabolism, although the exact mechanism remains unclear.
59 citations
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October 1976 in “BMJ” This case report observed that a child developed thrombocytopenia, characterized by a low platelet count and prolonged bleeding time, while on sodium valproate monotherapy for seizures.
November 2024 in “Journal of Cosmetic Dermatology” This study found that valproic acid-loaded microemulsion formulations enhanced skin penetration pathways in guinea pigs compared to an aqueous solution, with composition elements like oil content and surfactant ratios significantly affecting drug delivery performance.
68 citations
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March 2018 in “Biomaterials” This study found that in vivo, a novel microneedle system for valproic acid delivery may improve hair regrowth efficacy by upregulating hair follicle development pathways more effectively than topical application.
1 citations
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December 2024 in “ACS Biomaterials Science & Engineering” The patches could quickly deliver epilepsy treatment and reduce seizures.
February 2025 in “International Journal of Morphology” In this study conducted on mouse fetuses, valproic acid was found to reduce Sonic Hedgehog expression in the skin and hair follicles, but the inclusion of vitamin E helped mitigate this effect, supporting its potential role in managing valproic acid-induced changes.
January 2026 in “Open Science Framework” This scoping review aims to map current knowledge about treatment strategies for alopecia caused by VPA (valproic acid) across various patient groups, identifying reported management strategies, supporting evidence, observed outcomes, and areas needing further research, but results are not provided.
16 citations
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January 2000 in “Journal of dermatological treatment” This study found that calcipotriol scalp solution was more effective than a coal tar-based shampoo for treating mild to moderate scalp psoriasis and showed continued efficacy with long-term use.
107 citations
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August 2002 in “Journal of Neurology, Neurosurgery, and Psychiatry” Women with epilepsy should be monitored for reproductive issues, which can be caused by epilepsy or its treatments, especially when using valproate.
April 2025 in “European Psychiatry” This systematic review and meta-analysis found that mood stabilizers used for bipolar disorder, such as lithium, valproate, carbamazepine, and lamotrigine, resulted in varying prevalence of dermatologic side effects, with lamotrigine showing the highest rash incidence, while severe reactions were rare.
4 citations
,
October 2015 in “JAAD Case Reports” This case report describes a patient experiencing nail nonadherence due to sterile matrix scarring associated with valproic acid use, and suggests nail bed excision with sterile matrix grafting as a potential surgical solution.
6 citations
,
January 2012 in “Annals of Indian Academy of Neurology” This study found that women with epilepsy on carbamazepine and sodium valproate monotherapy experienced more significant weight gain but showed no difference in PCOS incidence compared to phenytoin users; elevated TSH levels were more common among those on sodium valproate.
January 2019 in “Pediatric Oncall” This article reviews the use of valproate in epilepsy treatment and its side effects, noting that hair texture changes such as curly hair are a rarely reported effect, but reports no new clinical results.
January 2017 in “SHILAP Revista de lepidopterología” Agomelatine might help reduce hair loss caused by valproate.
2 citations
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January 2017 in “Düşünen Adam” Agomelatine might help stop hair loss caused by valproate.
3 citations
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October 1976 in “BMJ” In this case report, a 6-year-old boy developed thrombocytopenia while taking sodium valproate alone, after being seizure-free for eight months on the medication.
September 2025 in “Indian Journal of Psychiatry” This study found that individuals taking valproate had a higher incidence of hair loss and reported an association between valproate levels, reduced biotinidase activity, and hair loss, compared to a control group.
15 citations
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May 2006 in “Brain & development” The authors concluded that administering biotin may help prevent alopecia caused by reduced biotinidase activity during valproic acid therapy in rats.
July 2008 in “European Journal of Cancer Supplements” This article provides an overview of the indications, interactions, and various potential adverse reactions associated with several drugs, but it reports no specific new results.
1 citations
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January 1999 in “The European journal of contraception & reproductive health care” This study found that a low-dose oral contraceptive containing dienogest provides effective contraception, improves cycle stability, and may reduce excessive scalp and skin oiliness, with high user satisfaction.