Sterile Matrix Grafting for Onycholysis in the Setting of Valproic Acid Use

    October 2015 in “ JAAD Case Reports
    Oriana Cohen, Sheel Sharma
    TLDR Surgical grafting may fix nail issues caused by valproic acid.
    Valproic acid (VPA), commonly used for epilepsy and mood stabilization, was known to cause various skin-related side effects, including temporary hair loss. The document reported a case where a patient experienced nail nonadherence due to sterile matrix scarring while using VPA. The authors proposed a surgical intervention involving nail bed excision and sterile matrix grafting as a potential solution for this condition.
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