Investigating the Synergic Effects of Valproic Acid and Crocin on BDNF and GDNF Expression in Epidermal Neural Crest Stem Cells

    January 2020 in “ Acta Neurobiologiae Experimentalis ”
    Zahra Baharvand, Mohammad Nabiuni, Mohammad Tahmaseb, Elaheh Amini, Sareh Pandamooz
    TLDR Valproic acid and crocin together boost cell growth and may help treat nerve injuries.
    The study investigated the effects of valproic acid (VPA) and crocin on the expression of brain-derived neurotrophic factor (BDNF) and glial-cell-derived neurotrophic factor (GDNF) in epidermal neural crest stem cells (EPI-NCSCs) isolated from rat hair follicles. The research found that treating these stem cells with 1 mM VPA and 1.5 mM crocin, as well as co-treating with 1 mM VPA and 500 μM crocin, promoted cell survival and proliferation. Real-time PCR results showed that both VPA and crocin, individually and in combination, significantly increased BDNF and GDNF expression levels. These findings suggested that VPA and crocin could enhance the differentiation capacity of EPI-NCSCs into neural lineages, making them potential candidates for treating neurological disorders like spinal cord injury.
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