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180-210 / 1000+ resultsresearch Sex Differences in Animal Models of Sodium-Valproate-Induced Autism in Postnatal BALB/c Mice: Whole-Brain Histoarchitecture and 5-HT2A Receptor Biomarker Evidence
This study concluded that male mice are more susceptible to valproic acid-induced autism spectrum disorder than female mice, with noticeable differences in brain histoarchitecture and receptor protein levels.
research Adapalene–benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients
The adapalene-benzoyl peroxide gel works better and faster for acne treatment than using either ingredient alone, with manageable side effects.
research Progesterone and its Metabolites: Anticonvulsant and Behavioral Studies
In this study, progesterone showed anticonvulsant effects in mice via a mechanism that is at least partially independent of its metabolism to THP, without significant psychotoxicity.
research Cosmetic effects of anti-epileptic drugs among adult Sudanese epileptic patients
This study found that despite cosmetic effects from antiepileptic drugs like hair loss and weight gain, Sudanese epilepsy patients generally prioritized medication adherence, potentially influenced by cultural perceptions.
research Dipyridamole-Associated Shock and Pulmonary Edema; Oxcarbazepine-Induced Resistant Ventricular Fibrillation; Finasteride-Induced Pseudoporphyria; Suicidal Ideation Associated with Asenapine; Rediscovering Adverse Anticholinergic Effects; Prevalence of Adverse Drug Events in Ambulatory Care
This article highlights the importance of recognizing, preventing, and reporting adverse drug reactions to the FDA's MedWatch program, but does not present new research findings.
research Dovobet ointment under occlusion overnight for troublesome scalp psoriasis
Dovobet ointment used overnight effectively reduces scalp psoriasis severity and itch.
research Venlafaxine induced hair loss: a case report
This case report suggests that venlafaxine may cause hair loss in some patients, as demonstrated by a patient whose hair loss ceased after stopping the medication.
research Acneiform Rash Caused by an Unlikely Drug: Topiramate
This case report describes a 35-year-old man who developed an atypical DRESS syndrome after taking topiramate for migraine prevention, which resolved with drug withdrawal and symptomatic treatment.
research Attenuating 5α-pregnane-3α-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures
The researchers reported that metabolism of progesterone to 3α,5α-THP in the hippocampus is important for its antiseizure effects in ovariectomized rats.
research Successful etanercept therapy in therapy refractory acrodermatitis continua suppurativa Hallopeau
In this case report, etanercept was observed to effectively resolve symptoms of refractory acrodermatitis continua suppurativa Hallopeau after previous treatments had limited success.
research Finasteride may increase risk of seizures
research Perampanel‐induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome
In this case report, a 13-year-old girl with Pitt-Hopkins syndrome developed hair curling after starting the antiepileptic drug perampanel, which had not been previously reported as a side effect.
research P175 The effects of biotin supplementation on alopecia in rats which were administrated to valproic acid
Biotin supplements did not significantly reduce hair loss in rats on valproic acid.
research The Antiepileptic and Antidepressant-Like Effects of Dexpanthenol in Female Swiss Albino Mice
In this study, dexpanthenol exhibited antiepileptic and antidepressant-like effects in mice without impacting their motor coordination.
research PHARMACOVIGILANCE STUDY OF SIDE EFFECTS ASSOCIATED WITH LEVONORGESTROL -ETHINYL ESTRADIOL AND DEPOTMEDROXY PROGESTERONE ACETATE
This study observed that women using combined oral contraceptives experienced more nausea, vomiting, and hair loss, while those on Depo-Provera were more likely to gain weight.
research A CASE REPORT OF PARANOID DELUSION WITH VENLAFAXINE USE
This case study documents a potential relationship between venlafaxine use and the onset of paranoia, which resolved upon discontinuation and recurred when reintroduced.
research Enzalutamide/finasteride/goserelin/zoledronic-acid
research Difficult-to-Treat Idiopathic Generalized Epilepsy in a Young Woman
This case study reports that a combination of levetiracetam, zonisamide, and lamotrigine effectively eliminated seizures in a patient with juvenile myoclonic epilepsy, after initial treatments failed.
research Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors
This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.
research Abstract- Poster
This case report describes a patient who developed a maculopapular rash after starting lithium treatment, highlighting the importance of monitoring skin reactions due to potential impact on treatment adherence.
research Calcipotriene plus betamethasone dipropionate gel: a new combination therapy for scalp psoriasis
This study found that the once-daily gel combining calcipotriene and betamethasone dipropionate was more effective and faster in treating scalp psoriasis compared to individual treatments, with a similar safety profile.
research Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia
This study investigated a new formula called SV-loaded nanospanlastics for topical application to treat androgenic alopecia. It showed similar effectiveness to minoxidil lotion but with fewer adverse effects when used to enhance dermal delivery and efficacy of sodium valproate.
research Progesterone-induced spike-wave discharges are inhibited by finasteride
This study found that finasteride blocked the progesterone-induced increase in spike-wave discharges in rats, suggesting that this effect of progesterone is mediated by its metabolite allopregnanolone.
research Effect of the allopregnanolone and allotetrahydrodeoxycorticosteron on spike-wave discharges in the EEG of absence epilepsy rat models
In this study, finasteride-treated WAG/Rij rats showed a significant increase in spike-wave discharges when administered endogenous steroids THPROG and THDOC, indicating potential exacerbation of absence seizures.
research Neurosteroids as Endogenous Regulators of Seizure Susceptibility
This study found that deoxycorticosterone-derived neurosteroids modulate GABA A receptor function and may influence stress-induced changes in seizure susceptibility by elevating seizure thresholds in animal models.
research Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice.
This study found that the anticonvulsant effects of progesterone against PTZ-induced seizures in mice require conversion to allopregnanolone, as shown by the reversal of these effects with a 5alpha-reductase inhibitor.
research The effect of 2 combined oral Contraceptives containing either drospirenone or cyproterone acetate on acne and seborrhea.
This study found that the oral contraceptive containing drospirenone (EE/DRSP) was as effective as EE/CPA in reducing acne lesions, sebum production, and hair growth in women with acne.
research 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder
In this study, high-dose dutasteride significantly reduced several core symptoms of PMDD compared to placebo, supporting the role of neurosteroids in this condition.
research Depo-Provera: an injectable contraceptive.
This article reviews the contraceptive agent Depo-Provera, discussing its effectiveness, potential side effects, and safety concerns, but reports no new clinical results.