Temporal Lobe Epilepsy Exacerbation During Pharmacological Inhibition of Endogenous Neurosteroid Synthesis

    February 2013 in “ BMJ Case Reports ”
    Matteo Pugnaghi, Giulia Monti, Giuseppe Biagini, Stefano Meletti
    Studysummary This case report suggests that discontinuing finasteride, which may affect neurosteroids synthesis, improved seizure control in a woman with temporal lobe seizures.
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    Research cited in this study 2

    1. Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis Epilepsy & Behavior · 2012
    2. Endogenous Neurosteroids Modulate Epileptogenesis in a Model of Temporal Lobe Epilepsy Experimental Neurology · 2006

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