171 citations
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July 2007 in “Journal of Investigative Dermatology” The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.
96 citations
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March 2007 in “Developmental biology” This study found that the Wnt inhibitor Dkk4 may play a role in regulating hair follicle development through a feedback loop with canonical Wnt signaling pathways.
31 citations
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October 2010 in “BMB Reports” In this study, L-threonate was found to inhibit DHT-induced DKK-1 expression in cultured dermal papilla cells, suggesting it could help prevent androgen-driven balding.
19 citations
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January 2000 in “Biological and Pharmaceutical Bulletin” In this study, the researchers observed that the transdermal permeation mechanisms of diclofenac salts differ based on counterions, with varying pathways and routes for passive and iontophoretic transport.
16 citations
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September 2015 in “Journal of Ethnopharmacology” This review examines the long-standing use of "Dictamnus" in traditional medicine, highlighting the promising potential of D. albus and D. hispanicus as herbal drug candidates, but presents no new experimental findings.
13 citations
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November 2010 in “Experimental Dermatology” This study found that L-ascorbic acid 2-phosphate could reduce DHT-induced DKK-1 expression in balding scalp cells, suggesting potential for treating androgen-driven hair loss.
10 citations
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May 2020 in “Frontiers in cell and developmental biology” In this study, researchers found that Dicer, but not Tarbp2, plays a crucial role in regulating the growth phase of hair follicles in post-natal mice.
10 citations
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July 2015 in “Journal of Cosmetic Dermatology” This study found elevated tissue levels of DKK-1 in patients with both androgenetic alopecia and alopecia areata compared to controls, suggesting DKK-1 as a potential therapeutic target for these conditions.
9 citations
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January 2019 in “American Journal of Dermatopathology” This study found that both androgenetic alopecia and alopecia areata showed significantly increased DKK-1 expression, potentially implicating it in the pathogenesis and as a treatment target for these conditions.
6 citations
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January 2024 in “Annals of Dermatology” In this study, treatment with recombinant DKK2 was shown to significantly stimulate hair progenitor cell growth and enhance hair shaft elongation in ex vivo human hair follicle cultures by activating the Wnt/ẞ-catenin signaling pathway, suggesting a potential role for DKK2 in promoting hair growth.
5 citations
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February 2022 in “East African Journal of Science Technology and Innovation” This study evaluated a herbal shampoo containing flavonoid glycosides from Dicerocaryum senecioides and found that it successfully treated T. tonsurans infections in children's scalp when used daily, demonstrating significant effectiveness compared to a placebo.
5 citations
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July 2019 in “Applied statistics/Journal of the Royal Statistical Society. Series C, Applied statistics” In this study, applying case-only trees and random forests to a prostate cancer prevention trial revealed genotypes that may influence the efficacy of finasteride for prostate cancer prevention.
4 citations
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July 2020 in “Biochemical and Biophysical Research Communications” This study suggests that EDA-A2 induces apoptosis in hair follicles by increasing DKK-1 expression, implicating EDA2R signaling as a potential therapeutic target for androgenetic alopecia.
4 citations
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January 2017 in “Annals of Dermatology” Tianeptine may help prevent hair loss by promoting hair growth and reducing cell death.
3 citations
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December 2013 in “Balkan Journal of Medical Genetics” This case report highlights the use of microarray analysis to identify cryptic chromosomal rearrangements in a young woman with intellectual disability and multiple congenital anomalies.
3 citations
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March 1956 in “PubMed” This study discusses a surgical skin planing procedure using new technology and freezing agent that is reported to be a safe, effective treatment for cutaneous defects like pitted acne scars.
2 citations
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September 2023 in “JAAD Case Reports” This article discusses the chronic inflammatory skin diseases acne keloidalis nuchae and dissecting cellulitis of the scalp, focusing on their shared etiology and differing progression, and reports no new clinical findings.
2 citations
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October 2010 in “BMB Reports” In this study, L-threonate was observed to inhibit DHT-induced DKK-1 expression in dermal papilla cells and reverse DHT's inhibitory effects on outer root sheath cell growth, suggesting potential as a treatment for androgen-driven balding.
1 citations
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September 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that stress-induced inactivation of the enzyme Dicer in melanocytes can cause premature hair greying by preventing proper melanocyte placement and melanin transfer in mice, suggesting the Dicer-miR92b-ItgaV pathway as an important link between stress and grey hair.
1 citations
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January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study suggests that Dicer, but not Tarbp2, plays a crucial role in regulating the growth phase of hair follicles in bulge stem cells during post-natal development in mice.
December 2023 in “The journal of physical chemistry. B (1997 : Online)” This study explored the potential of human hair keratin as a filtration material, finding that it may effectively absorb the pollutants diclofenac and perfluorobutanesulfonate. The researchers reported significant binding affinities through molecular simulations, supporting further investigation into keratin's use for water purification.
This abstract is from a website with no specific study or research content, focusing on access to JAMA publications and administrative information.
January 2026 in “Aging and Disease” This review discusses recent research on the Dickkopf protein family's involvement in non-cancerous diseases and considers their potential as biomarkers and therapeutic targets without presenting new experimental results.
In this narrative case report, the authors discuss a patient recently diagnosed with an early-stage hematologic malignancy, highlighting her skepticism toward conventional medicine and preference for natural remedies over pharmaceutical treatments.
October 2022 in “Benha Journal of Applied Sciences” This article discusses the role of Dickkopf-1 as a Wnt antagonist affecting hair follicle signaling but does not report new findings on cicatricial or non-cicatricial alopecia.
April 2015 in “Reactions Weekly” Some elderly men had healing problems after using imiquimod and diclofenac for skin conditions on their scalps.
October 2014 in “Aktuelle Dermatologie” This study reports that elderly men with baldness and comorbid conditions experienced persistent scalp erosions following topical treatment with imiquimod or diclofenac, suggesting alternative therapies should be considered for this group.
January 2012 in “ScholarlyCommons (University of Pennsylvania)” This study found that miRNA biogenesis, facilitated by Dicer and Drosha, is crucial for adult hair follicles' growth and regeneration, highlighting their multiple roles during the hair follicle growth cycle.
January 2007 in “Chinese Journal of Analysis Laboratory” This study proposed a method to determine residual levels of dichloromethane and chloroform in finasteride using SPME-GC, reporting high linear correlation coefficients for both solvents.
December 2015 in “Journal of skin and stem cell” This study reports three cases where patients treated with topical 3% diclofenac gel for scalp actinic keratosis also experienced hair growth in androgenetic alopecia-affected areas.